Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains

C. Orsini, A. Bonito-Oliva, D. Conversi, S. Cabib

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Rationale: In previous studies, we have demonstrated that mice of the inbred strain C57BL/6J (C57) are more susceptible to amphetamine-induced conditioned place preference (CPP) than DBA/2J (DBA) mice. Moreover, we also observed parallel strain differences for the locomotor-stimulant effects of the drug. However, other studies have reported either no difference or opposite strain differences for cocaine- and morphine-induced CPP as well as for the locomotor effects of these drugs, suggesting that amphetamine-related behavioral phenotypes might depend on a specific pharmacological action of the psychostimulant. Objectives: This study was aimed at testing strain differences for cocaine- and morphine-related behavioral phenotypes in the same experimental protocol and conditions previously used for amphetamine. Methods: C57 and DBA mice were tested for CPP induced by cocaine (0, 5, 10, and 20 mg/kg) and morphine (0, 5, 7.5, and 10 mg/kg). Locomotor activity data were simultaneously obtained by measuring distance moved during all different CPP phases and unconditioned locomotor activity, behavioral sensitization and conditioned hyperactivity were measured together with CPP. Results: (a) Either cocaine or morphine promoted significant CPP at lower doses in C57 than in DBA mice; (b) only drug-trained C57 mice showed a significant CPP compared with the control group; and (c) only C57 mice showed dose-dependent effects of cocaine on CPP. Moreover, there was no relationship between drug-induced CPP and locomotion. Conclusions: The results demonstrate that C57 and DBA mice differ in their sensitivity to cocaine- and morphine-induced CPP and suggest that the two strains differ in sensitivity to the positive incentive properties of drugs of abuse.

Original languageEnglish
Pages (from-to)327-336
Number of pages10
JournalPsychopharmacology
Volume181
Issue number2
DOIs
Publication statusPublished - Sep 2005

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Inbred DBA Mouse
Inbred C57BL Mouse
Cocaine
Morphine
Amphetamine
Locomotion
Pharmaceutical Preparations
Phenotype
Inbred Strains Mice
Street Drugs
Motivation
Pharmacology
Control Groups

Keywords

  • Aversion
  • Cocaine
  • Genetics
  • Hyperactivity
  • Locomotor activity
  • Morphine
  • Sensitization

ASJC Scopus subject areas

  • Pharmacology

Cite this

Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. / Orsini, C.; Bonito-Oliva, A.; Conversi, D.; Cabib, S.

In: Psychopharmacology, Vol. 181, No. 2, 09.2005, p. 327-336.

Research output: Contribution to journalArticle

Orsini, C. ; Bonito-Oliva, A. ; Conversi, D. ; Cabib, S. / Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. In: Psychopharmacology. 2005 ; Vol. 181, No. 2. pp. 327-336.
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