Suscettibilità a diossina in soggetti cloracneici della popolazione di Seveso

M. Bonzini; A. Baccarelli; A. Pesatori; D. Consonni; D. Patterson; M. Rubagotti; N. E. Caporaso; P. A. Bertazzi; M. T. Landi

Suscettibilità a diossina in soggetti cloracneici della popolazione di Seveso

Translated title of the contribution: Susceptibility to dioxin among individuals from Seveso suffering from cloracne

M. Bonzini, A. Baccarelli, A. Pesatori, D. Consonni, D. Patterson, M. Rubagotti, N. E. Caporaso, P. A. Bertazzi, M. T. Landi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.

Translated title of the contribution	Susceptibility to dioxin among individuals from Seveso suffering from cloracne
Original language	Italian
Pages (from-to)	27-29
Number of pages	3
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	26
Issue number	4 SUPPL.
Publication status	Published - 2004

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Rehabilitation

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Suscettibilità a diossina in soggetti cloracneici della popolazione di Seveso. / Bonzini, M.; Baccarelli, A.; Pesatori, A.; Consonni, D.; Patterson, D.; Rubagotti, M.; Caporaso, N. E.; Bertazzi, P. A.; Landi, M. T.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 26, No. 4 SUPPL., 2004, p. 27-29.

Research output: Contribution to journal › Article › peer-review

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abstract = "Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.",

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AU - Bonzini, M.

AU - Baccarelli, A.

AU - Pesatori, A.

AU - Consonni, D.

AU - Patterson, D.

AU - Rubagotti, M.

AU - Caporaso, N. E.

AU - Bertazzi, P. A.

AU - Landi, M. T.

PY - 2004

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N2 - Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.

AB - Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.

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KW - Seveso accident

KW - Susceptibility

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