Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy: Effects of simvastatin treatment

Antonella Di Biase, Serafina Salvati, Rosaria Varí, Christina Avellino, Francesco Sforza, Marco Cappa, Roberta Masella

Research output: Contribution to journalArticle

Abstract

This paper shows for the first time the higher oxidizability of low-density lipoprotein (LDL) in plasma from adrenoleukodystrophy (ALD) patients compared to that of control subjects. LDL oxidation susceptibility was assessed by conjugate diene formation, hydroperoxide and lipoperoxide formation, and electrophoretic mobility. Simvastatin therapy, an HMG-CoA reductase inhibitor, seems to be a protective pharmacological agent against the higher oxidizability of LDL in plasma from ALD patients.

Original languageEnglish
Pages (from-to)651-655
Number of pages5
JournalMolecular Genetics and Metabolism
Volume71
Issue number4
DOIs
Publication statusPublished - 2000

Fingerprint

Lipoprotein-X
Adrenoleukodystrophy
Simvastatin
LDL Lipoproteins
Plasmas
Oxidation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Protective Agents
Electrophoretic mobility
Lipid Peroxides
Hydrogen Peroxide
Therapeutics
Pharmacology

Keywords

  • Adrenoleukodystrophy
  • Adrenomyeloneuropathy
  • Asymptomatic
  • Low-density lipoprotein
  • Oxidizability
  • Simvastatin

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy : Effects of simvastatin treatment. / Di Biase, Antonella; Salvati, Serafina; Varí, Rosaria; Avellino, Christina; Sforza, Francesco; Cappa, Marco; Masella, Roberta.

In: Molecular Genetics and Metabolism, Vol. 71, No. 4, 2000, p. 651-655.

Research output: Contribution to journalArticle

Di Biase, Antonella ; Salvati, Serafina ; Varí, Rosaria ; Avellino, Christina ; Sforza, Francesco ; Cappa, Marco ; Masella, Roberta. / Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy : Effects of simvastatin treatment. In: Molecular Genetics and Metabolism. 2000 ; Vol. 71, No. 4. pp. 651-655.
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