Suspected pharmacological interactions in a cancer patient during methadone maintenance

Gianluigi Ferretti, Serena Di Cosimo, Anna Ceribelli, Michele Milella, Alain Gelibter, Francesco Cognetti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 50-year-old man with chemotherapy resistant stage IV bronchioalveolar lung carcinoma had been managed successfully with oral methadone for opioid addiction for more than 30 years. Fifty days before admission, gefitinib, an oral epidermal growth factor receptor inhibitor, was prescribed. At admission he was confused with persistent hypotension. He received oxygen, bronchodilators, dexamethasone, ranitidine, and phenobarbital. The fifth in-hospital day, after developing the overdose syndrome, methadone was stopped. When he subsequently presented symptoms of withdrawal, methadone was reintroduced, but he continued displaying tachypnea, until he died for respiratory failure. Physicians should pay careful attention to the clinical respiratory symptoms and radiographic findings of these patients, especially during the first months after starting gefitinib. Further research into specific gefitinib interactions with the P450 enzyme systems is encouraged.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalAddictive Disorders and their Treatment
Volume3
Issue number2
DOIs
Publication statusPublished - 2004

Fingerprint

Methadone
Pharmacology
Tachypnea
Neoplasms
Substance Withdrawal Syndrome
Ranitidine
Bronchodilator Agents
Phenobarbital
Epidermal Growth Factor Receptor
Respiratory Insufficiency
Hypotension
Cytochrome P-450 Enzyme System
Dexamethasone
Opioid Analgesics
Oxygen
Carcinoma
Physicians
Drug Therapy
Lung
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Suspected pharmacological interactions in a cancer patient during methadone maintenance. / Ferretti, Gianluigi; Di Cosimo, Serena; Ceribelli, Anna; Milella, Michele; Gelibter, Alain; Cognetti, Francesco.

In: Addictive Disorders and their Treatment, Vol. 3, No. 2, 2004, p. 87-92.

Research output: Contribution to journalArticle

Ferretti, Gianluigi ; Di Cosimo, Serena ; Ceribelli, Anna ; Milella, Michele ; Gelibter, Alain ; Cognetti, Francesco. / Suspected pharmacological interactions in a cancer patient during methadone maintenance. In: Addictive Disorders and their Treatment. 2004 ; Vol. 3, No. 2. pp. 87-92.
@article{fad3ed844098459dbe9f9b2d8f9b4266,
title = "Suspected pharmacological interactions in a cancer patient during methadone maintenance",
abstract = "A 50-year-old man with chemotherapy resistant stage IV bronchioalveolar lung carcinoma had been managed successfully with oral methadone for opioid addiction for more than 30 years. Fifty days before admission, gefitinib, an oral epidermal growth factor receptor inhibitor, was prescribed. At admission he was confused with persistent hypotension. He received oxygen, bronchodilators, dexamethasone, ranitidine, and phenobarbital. The fifth in-hospital day, after developing the overdose syndrome, methadone was stopped. When he subsequently presented symptoms of withdrawal, methadone was reintroduced, but he continued displaying tachypnea, until he died for respiratory failure. Physicians should pay careful attention to the clinical respiratory symptoms and radiographic findings of these patients, especially during the first months after starting gefitinib. Further research into specific gefitinib interactions with the P450 enzyme systems is encouraged.",
author = "Gianluigi Ferretti and {Di Cosimo}, Serena and Anna Ceribelli and Michele Milella and Alain Gelibter and Francesco Cognetti",
year = "2004",
doi = "10.1097/00132576-200406000-00006",
language = "English",
volume = "3",
pages = "87--92",
journal = "Addictive Disorders and their Treatment",
issn = "1531-5754",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Suspected pharmacological interactions in a cancer patient during methadone maintenance

AU - Ferretti, Gianluigi

AU - Di Cosimo, Serena

AU - Ceribelli, Anna

AU - Milella, Michele

AU - Gelibter, Alain

AU - Cognetti, Francesco

PY - 2004

Y1 - 2004

N2 - A 50-year-old man with chemotherapy resistant stage IV bronchioalveolar lung carcinoma had been managed successfully with oral methadone for opioid addiction for more than 30 years. Fifty days before admission, gefitinib, an oral epidermal growth factor receptor inhibitor, was prescribed. At admission he was confused with persistent hypotension. He received oxygen, bronchodilators, dexamethasone, ranitidine, and phenobarbital. The fifth in-hospital day, after developing the overdose syndrome, methadone was stopped. When he subsequently presented symptoms of withdrawal, methadone was reintroduced, but he continued displaying tachypnea, until he died for respiratory failure. Physicians should pay careful attention to the clinical respiratory symptoms and radiographic findings of these patients, especially during the first months after starting gefitinib. Further research into specific gefitinib interactions with the P450 enzyme systems is encouraged.

AB - A 50-year-old man with chemotherapy resistant stage IV bronchioalveolar lung carcinoma had been managed successfully with oral methadone for opioid addiction for more than 30 years. Fifty days before admission, gefitinib, an oral epidermal growth factor receptor inhibitor, was prescribed. At admission he was confused with persistent hypotension. He received oxygen, bronchodilators, dexamethasone, ranitidine, and phenobarbital. The fifth in-hospital day, after developing the overdose syndrome, methadone was stopped. When he subsequently presented symptoms of withdrawal, methadone was reintroduced, but he continued displaying tachypnea, until he died for respiratory failure. Physicians should pay careful attention to the clinical respiratory symptoms and radiographic findings of these patients, especially during the first months after starting gefitinib. Further research into specific gefitinib interactions with the P450 enzyme systems is encouraged.

UR - http://www.scopus.com/inward/record.url?scp=2942602730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942602730&partnerID=8YFLogxK

U2 - 10.1097/00132576-200406000-00006

DO - 10.1097/00132576-200406000-00006

M3 - Article

AN - SCOPUS:2942602730

VL - 3

SP - 87

EP - 92

JO - Addictive Disorders and their Treatment

JF - Addictive Disorders and their Treatment

SN - 1531-5754

IS - 2

ER -