Abstract
Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores
Original language | English |
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Pages (from-to) | 380-385 |
Number of pages | 6 |
Journal | Neuropsychopharmacology |
Volume | 20 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 1999 |
Keywords
- Bipolar disorder
- Lithium
- Pindolol
- Sleep deprivation
ASJC Scopus subject areas
- Pharmacology