Abstract
Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores
| Original language | English |
|---|---|
| Pages (from-to) | 380-385 |
| Number of pages | 6 |
| Journal | Neuropsychopharmacology |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1999 |
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Keywords
- Bipolar disorder
- Lithium
- Pindolol
- Sleep deprivation
ASJC Scopus subject areas
- Pharmacology
Cite this
Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial. / Smeraldi, Enrico; Benedetti, Francesco; Barbini, Barbara; Campori, Euridice; Colombo, Cristina.
In: Neuropsychopharmacology, Vol. 20, No. 4, 04.1999, p. 380-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial
AU - Smeraldi, Enrico
AU - Benedetti, Francesco
AU - Barbini, Barbara
AU - Campori, Euridice
AU - Colombo, Cristina
PY - 1999/4
Y1 - 1999/4
N2 - Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores
AB - Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores
KW - Bipolar disorder
KW - Lithium
KW - Pindolol
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=0033059018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033059018&partnerID=8YFLogxK
U2 - 10.1016/S0893-133X(98)00129-8
DO - 10.1016/S0893-133X(98)00129-8
M3 - Article
C2 - 10088139
AN - SCOPUS:0033059018
VL - 20
SP - 380
EP - 385
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 4
ER -