Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial

Enrico Smeraldi; Francesco Benedetti; Barbara Barbini; Euridice Campori; Cristina Colombo

doi:10.1016/S0893-133X(98)00129-8

Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial

Enrico Smeraldi, Francesco Benedetti, Barbara Barbini, Euridice Campori, Cristina Colombo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores

Original language	English
Pages (from-to)	380-385
Number of pages	6
Journal	Neuropsychopharmacology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/S0893-133X(98)00129-8
Publication status	Published - Apr 1999

Keywords

Bipolar disorder
Lithium
Pindolol
Sleep deprivation

ASJC Scopus subject areas

Pharmacology

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AU - Colombo, Cristina

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