Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial

Enrico Smeraldi, Francesco Benedetti, Barbara Barbini, Euridice Campori, Cristina Colombo

Research output: Contribution to journalArticle

Abstract

Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalNeuropsychopharmacology
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 1999

Fingerprint

Pindolol
Sleep Deprivation
Bipolar Disorder
Antidepressive Agents
Placebos
Autoreceptors
Serotonin Uptake Inhibitors
Inpatients
Serotonin
Recurrence
Therapeutics

Keywords

  • Bipolar disorder
  • Lithium
  • Pindolol
  • Sleep deprivation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial. / Smeraldi, Enrico; Benedetti, Francesco; Barbini, Barbara; Campori, Euridice; Colombo, Cristina.

In: Neuropsychopharmacology, Vol. 20, No. 4, 04.1999, p. 380-385.

Research output: Contribution to journalArticle

@article{ee3a3040c55644e3a604104c79921d5e,
title = "Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial",
abstract = "Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores",
keywords = "Bipolar disorder, Lithium, Pindolol, Sleep deprivation",
author = "Enrico Smeraldi and Francesco Benedetti and Barbara Barbini and Euridice Campori and Cristina Colombo",
year = "1999",
month = "4",
doi = "10.1016/S0893-133X(98)00129-8",
language = "English",
volume = "20",
pages = "380--385",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial

AU - Smeraldi, Enrico

AU - Benedetti, Francesco

AU - Barbini, Barbara

AU - Campori, Euridice

AU - Colombo, Cristina

PY - 1999/4

Y1 - 1999/4

N2 - Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores

AB - Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT(1A) autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores

KW - Bipolar disorder

KW - Lithium

KW - Pindolol

KW - Sleep deprivation

UR - http://www.scopus.com/inward/record.url?scp=0033059018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033059018&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(98)00129-8

DO - 10.1016/S0893-133X(98)00129-8

M3 - Article

C2 - 10088139

AN - SCOPUS:0033059018

VL - 20

SP - 380

EP - 385

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 4

ER -