Sustained complete hematological remission in essential thrombocythemia after discontinuation of long-term α-IFN treatment

S. Sacchi, A. Tabilio, P. Leoni, A. Riccardi, A. Vecchi, C. Messora, L. Bensi, F. Falzetti, S. Rupoli, G. Ucci, M. F. Martelli

Research output: Contribution to journalArticle

Abstract

In essential thrombocythemia patients α-IFN rapidly reduces platelet count, and it is also able to maintain a low count during long-term treatment. In order to verify if long-term IFN treatment can produce sustained remission in selected patients, we decided to suspend IFN treatment in two subsets of 21 patients on long-term α-IFN treatment: (a) all six patients who had shown a platelet count below 450×109/l for at least 2 months with 3 MU once a week; (b) three patients who had shown the same platelet count for at least 2 months with 3 MU three times a week. After withdrawal of α-IFN treatment, a rapid increase in the platelet count was observed in all three patients requiring 3 MU three times a week. Three of the six patients treated with 3 MU once a week are still free of symptoms and have been in complete hematological remission (platelet count below 450×109/l) for 9+, 13+, and 14+ months, respectively. As far as the three remaining cases are concerned, one was not assessable because of loss to follow-up, while the other two relapsed after 1 and 2 months. We believe that the three cases of sustained remission might be the result of a long-term tumor load reduction produced by the α-IFN treatment. Finally, the factor best able to predict sustained, unmaintained remission seems to be the clinical response to a low dose of α-IFN during the maintenance phase, rather than disease features prior to treatment.

Original languageEnglish
Pages (from-to)245-246
Number of pages2
JournalAnnals of Hematology
Volume66
Issue number5
DOIs
Publication statusPublished - May 1993

Keywords

  • Essential thrombocythemia
  • Interferon-α
  • Sustained remission

ASJC Scopus subject areas

  • Hematology

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    Sacchi, S., Tabilio, A., Leoni, P., Riccardi, A., Vecchi, A., Messora, C., Bensi, L., Falzetti, F., Rupoli, S., Ucci, G., & Martelli, M. F. (1993). Sustained complete hematological remission in essential thrombocythemia after discontinuation of long-term α-IFN treatment. Annals of Hematology, 66(5), 245-246. https://doi.org/10.1007/BF01738473