Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex

Silvia Mangia, Ivan Tkáč, Rolf Gruetter, Pierre Francois Van De Moortele, Bruno Maraviglia, Kâmil Uǧurbil

Research output: Contribution to journalArticlepeer-review

Abstract

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in the human visual cortex during two paradigms of visual stimulation lasting 5.3 and 10.6 mins. Significant concentration changes of approximately 0.2 μmol/g were observed for several metabolites: lactate increased by 23%±5% (P

Original languageEnglish
Pages (from-to)1055-1063
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number5
DOIs
Publication statusPublished - May 16 2007

Keywords

  • H NMR spectroscopy
  • BOLD
  • Brain activation
  • Functional metabolism
  • In vivo
  • Lactate
  • Malate-aspartate shuttle

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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