Sutton's nevus and growth hormone therapy

E. Bozzola, R. Giacchero, S. Barberi, G. Borroni

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Growth hormone (GH) has been suggested to increase the growth of melanocytic nevi and the risk for melanoma in short children treated with substitutive therapy. On the contrary, in GH deficient patients the influence of GH treatment on the appearance and the long-term evolution of Sutton's nevus, a pigmented melanocytic lesion surrounded by a ring (halo) of depigmentation, that usually and progressively involves the nevus, is debated. The aim of this study was to investigate whether GH therapy causes an accelerated growth of Sutton's nevus. In our study, we evaluated 3 children with GH deficiency sharing Sutton's nevus to investigate the relationship between these melanocytic lesions and growth hormone. In case 1 the appearance of the nevus could be induced by hGH therapy. However, the lesion did not change in shape, colour and size even if he entered puberty during substitutive treatment. Moreover, Sutton's nevus is present in case 2, who is pre-puberal and not yet treated with hGH. In case 3 Sutton's nevi occurred during GH treatment and after the onset of puberty, but didn't show any long-term change in both the number and size. No clear influence of both GH therapy and sexual steroids on Sutton's nevi was observed.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalMinerva Pediatrica
Volume56
Issue number3
Publication statusPublished - Jun 2004

Fingerprint

Nevus
Growth Hormone
Pigmented Nevus
Therapeutics
Puberty
Nevi and Melanomas
Growth
Color
Steroids

Keywords

  • Growth hormone, deficiency
  • Growth hormone, therapy Steroids
  • Nevus
  • Somatotropin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bozzola, E., Giacchero, R., Barberi, S., & Borroni, G. (2004). Sutton's nevus and growth hormone therapy. Minerva Pediatrica, 56(3), 349-351.

Sutton's nevus and growth hormone therapy. / Bozzola, E.; Giacchero, R.; Barberi, S.; Borroni, G.

In: Minerva Pediatrica, Vol. 56, No. 3, 06.2004, p. 349-351.

Research output: Contribution to journalArticle

Bozzola, E, Giacchero, R, Barberi, S & Borroni, G 2004, 'Sutton's nevus and growth hormone therapy', Minerva Pediatrica, vol. 56, no. 3, pp. 349-351.
Bozzola E, Giacchero R, Barberi S, Borroni G. Sutton's nevus and growth hormone therapy. Minerva Pediatrica. 2004 Jun;56(3):349-351.
Bozzola, E. ; Giacchero, R. ; Barberi, S. ; Borroni, G. / Sutton's nevus and growth hormone therapy. In: Minerva Pediatrica. 2004 ; Vol. 56, No. 3. pp. 349-351.
@article{94db3a6b08994ebd95ac1356b644626a,
title = "Sutton's nevus and growth hormone therapy",
abstract = "Growth hormone (GH) has been suggested to increase the growth of melanocytic nevi and the risk for melanoma in short children treated with substitutive therapy. On the contrary, in GH deficient patients the influence of GH treatment on the appearance and the long-term evolution of Sutton's nevus, a pigmented melanocytic lesion surrounded by a ring (halo) of depigmentation, that usually and progressively involves the nevus, is debated. The aim of this study was to investigate whether GH therapy causes an accelerated growth of Sutton's nevus. In our study, we evaluated 3 children with GH deficiency sharing Sutton's nevus to investigate the relationship between these melanocytic lesions and growth hormone. In case 1 the appearance of the nevus could be induced by hGH therapy. However, the lesion did not change in shape, colour and size even if he entered puberty during substitutive treatment. Moreover, Sutton's nevus is present in case 2, who is pre-puberal and not yet treated with hGH. In case 3 Sutton's nevi occurred during GH treatment and after the onset of puberty, but didn't show any long-term change in both the number and size. No clear influence of both GH therapy and sexual steroids on Sutton's nevi was observed.",
keywords = "Growth hormone, deficiency, Growth hormone, therapy Steroids, Nevus, Somatotropin",
author = "E. Bozzola and R. Giacchero and S. Barberi and G. Borroni",
year = "2004",
month = "6",
language = "English",
volume = "56",
pages = "349--351",
journal = "Minerva Pediatrica",
issn = "0026-4946",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "3",

}

TY - JOUR

T1 - Sutton's nevus and growth hormone therapy

AU - Bozzola, E.

AU - Giacchero, R.

AU - Barberi, S.

AU - Borroni, G.

PY - 2004/6

Y1 - 2004/6

N2 - Growth hormone (GH) has been suggested to increase the growth of melanocytic nevi and the risk for melanoma in short children treated with substitutive therapy. On the contrary, in GH deficient patients the influence of GH treatment on the appearance and the long-term evolution of Sutton's nevus, a pigmented melanocytic lesion surrounded by a ring (halo) of depigmentation, that usually and progressively involves the nevus, is debated. The aim of this study was to investigate whether GH therapy causes an accelerated growth of Sutton's nevus. In our study, we evaluated 3 children with GH deficiency sharing Sutton's nevus to investigate the relationship between these melanocytic lesions and growth hormone. In case 1 the appearance of the nevus could be induced by hGH therapy. However, the lesion did not change in shape, colour and size even if he entered puberty during substitutive treatment. Moreover, Sutton's nevus is present in case 2, who is pre-puberal and not yet treated with hGH. In case 3 Sutton's nevi occurred during GH treatment and after the onset of puberty, but didn't show any long-term change in both the number and size. No clear influence of both GH therapy and sexual steroids on Sutton's nevi was observed.

AB - Growth hormone (GH) has been suggested to increase the growth of melanocytic nevi and the risk for melanoma in short children treated with substitutive therapy. On the contrary, in GH deficient patients the influence of GH treatment on the appearance and the long-term evolution of Sutton's nevus, a pigmented melanocytic lesion surrounded by a ring (halo) of depigmentation, that usually and progressively involves the nevus, is debated. The aim of this study was to investigate whether GH therapy causes an accelerated growth of Sutton's nevus. In our study, we evaluated 3 children with GH deficiency sharing Sutton's nevus to investigate the relationship between these melanocytic lesions and growth hormone. In case 1 the appearance of the nevus could be induced by hGH therapy. However, the lesion did not change in shape, colour and size even if he entered puberty during substitutive treatment. Moreover, Sutton's nevus is present in case 2, who is pre-puberal and not yet treated with hGH. In case 3 Sutton's nevi occurred during GH treatment and after the onset of puberty, but didn't show any long-term change in both the number and size. No clear influence of both GH therapy and sexual steroids on Sutton's nevi was observed.

KW - Growth hormone, deficiency

KW - Growth hormone, therapy Steroids

KW - Nevus

KW - Somatotropin

UR - http://www.scopus.com/inward/record.url?scp=3342974726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3342974726&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 349

EP - 351

JO - Minerva Pediatrica

JF - Minerva Pediatrica

SN - 0026-4946

IS - 3

ER -