SUVi and BACH1: A new subfamily of mammalian helicases?

P. Menichini, M. Linial

Research output: Contribution to journalArticlepeer-review

Abstract

The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalMutation Research - DNA Repair
Volume487
Issue number1-2
DOIs
Publication statusPublished - Nov 1 2001

Keywords

  • DNA helicases
  • Genome integrity
  • Genotoxic stress response
  • RecQ family

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Toxicology

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