SV40 and HIV sequences in the cerebrospinal fluid of a patient with AIDS dementia complex

Manola Comar, Pierlanfranco D'Agaro, Roberto Luzzati, Fernanda Martini, Mauro Tognon, Cesare Campello

Research output: Contribution to journalArticlepeer-review

Abstract

Central Nervous System (CNS) diseases that occur in HIV-positive patients are mainly due to HIV itself or to opportunistic microorganisms. Polyomavirus JCV, BKV and SV40 have been associated with encephalopathies in both HIV-positive and HIV-negative patients. To investigate the presence of Polyomavirus DNA sequences in patients affected by CNS disorders, 82 CSF samples from 70 HIV-positive and 12 HIV-negative patients were analyzed by PCR. A double HIV and SV40 infection was found in one patient suffering with AIDS dementia complex. SV40 DNA sequence analysis showed the homology with wild type SV40 stain. SV40 should be considered as a potential causal agent of CNS disorders in AIDS patients.

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalCurrent HIV Research
Volume5
Issue number3
DOIs
Publication statusPublished - May 2007

Keywords

  • AIDS dementia complex
  • Polyomavirus
  • SV40-HIV co-infection

ASJC Scopus subject areas

  • Infectious Diseases

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