TY - JOUR
T1 - SV40 and HIV sequences in the cerebrospinal fluid of a patient with AIDS dementia complex
AU - Comar, Manola
AU - D'Agaro, Pierlanfranco
AU - Luzzati, Roberto
AU - Martini, Fernanda
AU - Tognon, Mauro
AU - Campello, Cesare
PY - 2007/5
Y1 - 2007/5
N2 - Central Nervous System (CNS) diseases that occur in HIV-positive patients are mainly due to HIV itself or to opportunistic microorganisms. Polyomavirus JCV, BKV and SV40 have been associated with encephalopathies in both HIV-positive and HIV-negative patients. To investigate the presence of Polyomavirus DNA sequences in patients affected by CNS disorders, 82 CSF samples from 70 HIV-positive and 12 HIV-negative patients were analyzed by PCR. A double HIV and SV40 infection was found in one patient suffering with AIDS dementia complex. SV40 DNA sequence analysis showed the homology with wild type SV40 stain. SV40 should be considered as a potential causal agent of CNS disorders in AIDS patients.
AB - Central Nervous System (CNS) diseases that occur in HIV-positive patients are mainly due to HIV itself or to opportunistic microorganisms. Polyomavirus JCV, BKV and SV40 have been associated with encephalopathies in both HIV-positive and HIV-negative patients. To investigate the presence of Polyomavirus DNA sequences in patients affected by CNS disorders, 82 CSF samples from 70 HIV-positive and 12 HIV-negative patients were analyzed by PCR. A double HIV and SV40 infection was found in one patient suffering with AIDS dementia complex. SV40 DNA sequence analysis showed the homology with wild type SV40 stain. SV40 should be considered as a potential causal agent of CNS disorders in AIDS patients.
KW - AIDS dementia complex
KW - Polyomavirus
KW - SV40-HIV co-infection
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U2 - 10.2174/157016207780636560
DO - 10.2174/157016207780636560
M3 - Article
C2 - 17504176
AN - SCOPUS:34249034697
VL - 5
SP - 345
EP - 347
JO - Current HIV Research
JF - Current HIV Research
SN - 1570-162X
IS - 3
ER -