SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: A molecular epidemiologic case-control study

Alfonso Cristaudo, Rudy Foddis, Agnese Vivaldi, Rodolfo Buselli, Vittorio Gattini, Giovanni Guglielmi, Francesca Cosentino, Franco Ottenga, Eugenio Ciancia, Roberta Libener, Rosangela Filiberti, Monica Neri, PierGiacoino Betta, Mauro Tognon, Luciano Mutti, Riccardo Puntoni

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Abstract

We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.

Original languageEnglish
Pages (from-to)3049-3052
Number of pages4
JournalCancer Research
Volume65
Issue number8
Publication statusPublished - Apr 15 2005

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cristaudo, A., Foddis, R., Vivaldi, A., Buselli, R., Gattini, V., Guglielmi, G., Cosentino, F., Ottenga, F., Ciancia, E., Libener, R., Filiberti, R., Neri, M., Betta, P., Tognon, M., Mutti, L., & Puntoni, R. (2005). SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: A molecular epidemiologic case-control study. Cancer Research, 65(8), 3049-3052.