SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells

A. Albini, G. Allavena, H. Richter, B. F. Pontz, S. Parodi, L. Santi

Research output: Contribution to journalArticle

Abstract

SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalExperientia
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 1985

Fingerprint

Fibroblasts
Fibronectins
Simian virus 40
Viruses
Chemotactic Factors
Chemotaxis
Glycoproteins
Molecules

Keywords

  • chemotaxis
  • domains
  • fibroblasts
  • Fibronectin
  • SV40

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells. / Albini, A.; Allavena, G.; Richter, H.; Pontz, B. F.; Parodi, S.; Santi, L.

In: Experientia, Vol. 41, No. 12, 12.1985, p. 1591-1593.

Research output: Contribution to journalArticle

Albini, A. ; Allavena, G. ; Richter, H. ; Pontz, B. F. ; Parodi, S. ; Santi, L. / SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells. In: Experientia. 1985 ; Vol. 41, No. 12. pp. 1591-1593.
@article{ae0543008753426e92b025b1a59924a9,
title = "SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells",
abstract = "SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.",
keywords = "chemotaxis, domains, fibroblasts, Fibronectin, SV40",
author = "A. Albini and G. Allavena and H. Richter and Pontz, {B. F.} and S. Parodi and L. Santi",
year = "1985",
month = "12",
doi = "10.1007/BF01964822",
language = "English",
volume = "41",
pages = "1591--1593",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "12",

}

TY - JOUR

T1 - SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells

AU - Albini, A.

AU - Allavena, G.

AU - Richter, H.

AU - Pontz, B. F.

AU - Parodi, S.

AU - Santi, L.

PY - 1985/12

Y1 - 1985/12

N2 - SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.

AB - SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.

KW - chemotaxis

KW - domains

KW - fibroblasts

KW - Fibronectin

KW - SV40

UR - http://www.scopus.com/inward/record.url?scp=0022365373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022365373&partnerID=8YFLogxK

U2 - 10.1007/BF01964822

DO - 10.1007/BF01964822

M3 - Article

C2 - 3000816

AN - SCOPUS:0022365373

VL - 41

SP - 1591

EP - 1593

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 12

ER -