SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells

A. Albini, G. Allavena, H. Richter, B. F. Pontz, S. Parodi, L. Santi

Research output: Contribution to journalArticle

Abstract

SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalExperientia
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 1985

Keywords

  • chemotaxis
  • domains
  • fibroblasts
  • Fibronectin
  • SV40

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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