SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis

Paula Coutinho Toto; Pier Lorenzo Puri; Sonia Albini

doi:10.1007/s00018-016-2273-3

SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis

Paula Coutinho Toto, Pier Lorenzo Puri, Sonia Albini

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic modifications that determine whether stem cells maintain pluripotency or commit toward specific lineages through development and during postnatal life. Dynamic combinatorial assembly of multiple variants of SWI/SNF subunits is emerging as the major determinant of the functional versatility of SWI/SNF. Here, we summarize the current knowledge on the structural and functional properties of the alternative SWI/SNF complexes that direct stem cell fate toward skeletal muscle lineage and control distinct stages of skeletal myogenesis. In particular, we will refer to recent evidence pointing to the essential role of two SWI/SNF components not expressed in embryonic stem cells—the catalytic subunit BRM and the structural component BAF60C—whose induction in muscle progenitors coincides with the expansion of their transcriptional repertoire.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Cellular and Molecular Life Sciences
DOIs	https://doi.org/10.1007/s00018-016-2273-3
Publication status	Accepted/In press - May 20 2016

Keywords

BAF60C
BRM
Epigenetics
Skeletal muscle
Stem cells
SWI/SNF

ASJC Scopus subject areas

Cell Biology
Molecular Biology
Molecular Medicine
Pharmacology
Cellular and Molecular Neuroscience

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10.1007/s00018-016-2273-3

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title = "SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis",

abstract = "SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic modifications that determine whether stem cells maintain pluripotency or commit toward specific lineages through development and during postnatal life. Dynamic combinatorial assembly of multiple variants of SWI/SNF subunits is emerging as the major determinant of the functional versatility of SWI/SNF. Here, we summarize the current knowledge on the structural and functional properties of the alternative SWI/SNF complexes that direct stem cell fate toward skeletal muscle lineage and control distinct stages of skeletal myogenesis. In particular, we will refer to recent evidence pointing to the essential role of two SWI/SNF components not expressed in embryonic stem cells—the catalytic subunit BRM and the structural component BAF60C—whose induction in muscle progenitors coincides with the expansion of their transcriptional repertoire.",

keywords = "BAF60C, BRM, Epigenetics, Skeletal muscle, Stem cells, SWI/SNF",

author = "Toto, {Paula Coutinho} and Puri, {Pier Lorenzo} and Sonia Albini",

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doi = "10.1007/s00018-016-2273-3",

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AU - Puri, Pier Lorenzo

AU - Albini, Sonia

PY - 2016/5/20

Y1 - 2016/5/20

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KW - Skeletal muscle

KW - Stem cells

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SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis

Abstract

Keywords

ASJC Scopus subject areas

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