Abstract
SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic modifications that determine whether stem cells maintain pluripotency or commit toward specific lineages through development and during postnatal life. Dynamic combinatorial assembly of multiple variants of SWI/SNF subunits is emerging as the major determinant of the functional versatility of SWI/SNF. Here, we summarize the current knowledge on the structural and functional properties of the alternative SWI/SNF complexes that direct stem cell fate toward skeletal muscle lineage and control distinct stages of skeletal myogenesis. In particular, we will refer to recent evidence pointing to the essential role of two SWI/SNF components not expressed in embryonic stem cells—the catalytic subunit BRM and the structural component BAF60C—whose induction in muscle progenitors coincides with the expansion of their transcriptional repertoire.
| Original language | English |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Cellular and Molecular Life Sciences |
| DOIs | |
| Publication status | Accepted/In press - May 20 2016 |
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Keywords
- BAF60C
- BRM
- Epigenetics
- Skeletal muscle
- Stem cells
- SWI/SNF
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Molecular Medicine
- Pharmacology
- Cellular and Molecular Neuroscience
Cite this
SWI/SNF-directed stem cell lineage specification : dynamic composition regulates specific stages of skeletal myogenesis. / Toto, Paula Coutinho; Puri, Pier Lorenzo; Albini, Sonia.
In: Cellular and Molecular Life Sciences, 20.05.2016, p. 1-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SWI/SNF-directed stem cell lineage specification
T2 - dynamic composition regulates specific stages of skeletal myogenesis
AU - Toto, Paula Coutinho
AU - Puri, Pier Lorenzo
AU - Albini, Sonia
PY - 2016/5/20
Y1 - 2016/5/20
N2 - SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic modifications that determine whether stem cells maintain pluripotency or commit toward specific lineages through development and during postnatal life. Dynamic combinatorial assembly of multiple variants of SWI/SNF subunits is emerging as the major determinant of the functional versatility of SWI/SNF. Here, we summarize the current knowledge on the structural and functional properties of the alternative SWI/SNF complexes that direct stem cell fate toward skeletal muscle lineage and control distinct stages of skeletal myogenesis. In particular, we will refer to recent evidence pointing to the essential role of two SWI/SNF components not expressed in embryonic stem cells—the catalytic subunit BRM and the structural component BAF60C—whose induction in muscle progenitors coincides with the expansion of their transcriptional repertoire.
AB - SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic modifications that determine whether stem cells maintain pluripotency or commit toward specific lineages through development and during postnatal life. Dynamic combinatorial assembly of multiple variants of SWI/SNF subunits is emerging as the major determinant of the functional versatility of SWI/SNF. Here, we summarize the current knowledge on the structural and functional properties of the alternative SWI/SNF complexes that direct stem cell fate toward skeletal muscle lineage and control distinct stages of skeletal myogenesis. In particular, we will refer to recent evidence pointing to the essential role of two SWI/SNF components not expressed in embryonic stem cells—the catalytic subunit BRM and the structural component BAF60C—whose induction in muscle progenitors coincides with the expansion of their transcriptional repertoire.
KW - BAF60C
KW - BRM
KW - Epigenetics
KW - Skeletal muscle
KW - Stem cells
KW - SWI/SNF
UR - http://www.scopus.com/inward/record.url?scp=84969902601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969902601&partnerID=8YFLogxK
U2 - 10.1007/s00018-016-2273-3
DO - 10.1007/s00018-016-2273-3
M3 - Article
SP - 1
EP - 10
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
ER -