Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England)

A Castagna; S Rusconi; R Gulminetti; S Bonora; G Mazzola; ME Quiros-Roldan; GV De Socio; N Ladisa; S Carosella; A Cattelan; S Di Giambenedetto; M Mena; A Poli; L Galli; A Riva; on behalf of the DAU Study Group

doi:10.1097/QAD.0000000000002188

Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England)

A Castagna, S Rusconi, R Gulminetti, S Bonora, G Mazzola, ME Quiros-Roldan, GV De Socio, N Ladisa, S Carosella, A Cattelan, S Di Giambenedetto, M Mena, A Poli, L Galli, A Riva, on behalf of the DAU Study Group

IRCCS Ospedale San Raffaele

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Abstract

We evaluated the efficacy and safety of a two-drug regimen including dolutegravir (DTG) and unboosted atazanavir (uATV) in 151 HIV-1 infected patients with HIV-RNA of more than 50 copies/ml. During a median follow-up of 62 (42-97) weeks, two virological failures (1%) and 13 treatment discontinuations (9%) occurred; the 48-week probability of virological failure was 0.8% (95% confidence interval 0.2-5.6%). Switch to DTG + uATV may represent a boosting and transcriptase reverse inhibitors sparing otion in individuals with long exposure to antiretroviral therapy and risk of cardiovascular disease.

Original language	English
Pages (from-to)	1256-1260
Number of pages	5
Journal	AIDS
Volume	33
Issue number	7
DOIs	https://doi.org/10.1097/QAD.0000000000002188
Publication status	Published - 2019

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Castagna, A., Rusconi, S., Gulminetti, R., Bonora, S., Mazzola, G., Quiros-Roldan, ME., De Socio, GV., Ladisa, N., Carosella, S., Cattelan, A., Di Giambenedetto, S., Mena, M., Poli, A., Galli, L., Riva, A., & Group, O. B. O. T. DAU. S. (2019). Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England). AIDS, 33(7), 1256-1260. https://doi.org/10.1097/QAD.0000000000002188

Castagna, A, Rusconi, S, Gulminetti, R, Bonora, S, Mazzola, G, Quiros-Roldan, ME, De Socio, GV, Ladisa, N, Carosella, S, Cattelan, A, Di Giambenedetto, S, Mena, M, Poli, A , Galli, L, Riva, A & Group, OBOTDAUS 2019, 'Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England)', AIDS, vol. 33, no. 7, pp. 1256-1260. https://doi.org/10.1097/QAD.0000000000002188

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title = "Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England)",

abstract = "We evaluated the efficacy and safety of a two-drug regimen including dolutegravir (DTG) and unboosted atazanavir (uATV) in 151 HIV-1 infected patients with HIV-RNA of more than 50 copies/ml. During a median follow-up of 62 (42-97) weeks, two virological failures (1%) and 13 treatment discontinuations (9%) occurred; the 48-week probability of virological failure was 0.8% (95% confidence interval 0.2-5.6%). Switch to DTG + uATV may represent a boosting and transcriptase reverse inhibitors sparing otion in individuals with long exposure to antiretroviral therapy and risk of cardiovascular disease.",

author = "A Castagna and S Rusconi and R Gulminetti and S Bonora and G Mazzola and ME Quiros-Roldan and {De Socio}, GV and N Ladisa and S Carosella and A Cattelan and {Di Giambenedetto}, S and M Mena and A Poli and L Galli and A Riva and Group, {on behalf of the DAU Study}",

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doi = "10.1097/QAD.0000000000002188",

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AU - Castagna, A

AU - Rusconi, S

AU - Gulminetti, R

AU - Bonora, S

AU - Mazzola, G

AU - Quiros-Roldan, ME

AU - De Socio, GV

AU - Ladisa, N

AU - Carosella, S

AU - Cattelan, A

AU - Di Giambenedetto, S

AU - Mena, M

AU - Poli, A

AU - Galli, L

AU - Riva, A

AU - Group, on behalf of the DAU Study

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AB - We evaluated the efficacy and safety of a two-drug regimen including dolutegravir (DTG) and unboosted atazanavir (uATV) in 151 HIV-1 infected patients with HIV-RNA of more than 50 copies/ml. During a median follow-up of 62 (42-97) weeks, two virological failures (1%) and 13 treatment discontinuations (9%) occurred; the 48-week probability of virological failure was 0.8% (95% confidence interval 0.2-5.6%). Switch to DTG + uATV may represent a boosting and transcriptase reverse inhibitors sparing otion in individuals with long exposure to antiretroviral therapy and risk of cardiovascular disease.

U2 - 10.1097/QAD.0000000000002188

DO - 10.1097/QAD.0000000000002188

M3 - Article

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JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 7

ER -

Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy: AIDS (London, England)

Abstract

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