Switching from infliximab or etanercept to adalimumab in resistant or intolerant patients with spondyloarthritis: A 4-year study

Antonio Spadaro, Leonardo Punzi, Antonio Marchesoni, Ennio Lubrano, Alessandro Mathieu, Fabrizio Cantini, Ignazio Olivieri, Carlo Salvarani, Raffaele Scarpa, Rossana Scrivo, Roberta Ramonda, Giovanni Porru, Salvatore D'Angelo, Mariagrazia Catanoso, Mariangela Atteno, Guido Valesini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: TNF-α antagonists, infliximab (INF), etanercept (ETA) and adalimumab (ADA), have been demonstrated to be effective in controlling symptoms in SpAs. The aim of this study was to investigate the possibility of using ADA as a second or third choice. Methods: A retrospective study was conducted in patients with SpA treated with TNF-α blockers who switched from INF or ETA to ADA, for inefficacy or adverse events. Kaplan-Meier survival curves were plotted to determine the rates of continuation of the first treatment (INF or ETA) as compared with the rates of continuation of the second or third treatment with ADA. Results: A total of 1619 patients with SpA were treated with INF (35.3%), ETA (43.7%) and ADA (20.9%). In this cohort, ADA was started in 38 (2.34%) patients as a second anti-TNF-α drug and in 9 (0.56%) as a third anti-TNF-α drug. In SpA patients who failed the first anti-TNF-α, for whatever reason, survival curves for ADA (as a second anti-TNF-α) were significantly better than survival curves for these same patients on their first anti-TNF-α (overall: P

Original languageEnglish
Article numberkeq008
Pages (from-to)1107-1111
Number of pages5
JournalRheumatology
Volume49
Issue number6
DOIs
Publication statusPublished - Mar 11 2010

Keywords

  • Ankylosing spondylitis
  • Anti-TNF drugs
  • Psoriatic arthritis
  • Spondylarthropathies

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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