Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy

L. Sarmati; S. G. Parisi; C. Andreoni; E. Nicastri; A. R. Buonomini; C. Boldrin; L. Dori; M. Montano; C. Tommasi; S. Andreis; V. Vullo; G. Palù; M. Andreoni

doi:10.1128/JCM.02125-09

Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy

L. Sarmati, S. G. Parisi, C. Andreoni, E. Nicastri, A. R. Buonomini, C. Boldrin, L. Dori, M. Montano, C. Tommasi, S. Andreis, V. Vullo, G. Palù, M. Andreoni

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4 ⁺ T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.

Original language	English
Pages (from-to)	2586-2588
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	48
Issue number	7
DOIs	https://doi.org/10.1128/JCM.02125-09
Publication status	Published - 2010

ASJC Scopus subject areas

Microbiology (medical)
Medicine(all)

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Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy. / Sarmati, L.; Parisi, S. G.; Andreoni, C.; Nicastri, E.; Buonomini, A. R.; Boldrin, C.; Dori, L.; Montano, M.; Tommasi, C.; Andreis, S.; Vullo, V.; Palù, G.; Andreoni, M.

In: Journal of Clinical Microbiology, Vol. 48, No. 7, 2010, p. 2586-2588.

Research output: Contribution to journal › Article › peer-review

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AU - Buonomini, A. R.

AU - Boldrin, C.

AU - Dori, L.

AU - Montano, M.

AU - Tommasi, C.

AU - Andreis, S.

AU - Vullo, V.

AU - Palù, G.

AU - Andreoni, M.

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