Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy

L. Sarmati, S. G. Parisi, C. Andreoni, E. Nicastri, A. R. Buonomini, C. Boldrin, L. Dori, M. Montano, C. Tommasi, S. Andreis, V. Vullo, G. Palù, M. Andreoni

Research output: Contribution to journalArticlepeer-review

Abstract

After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4 + T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.

Original languageEnglish
Pages (from-to)2586-2588
Number of pages3
JournalJournal of Clinical Microbiology
Volume48
Issue number7
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Microbiology (medical)
  • Medicine(all)

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