Switching on the deep brain stimulation: Effects on cardiovascular regulation and respiration

S. Vigneri, P. Guaraldi, G. Calandra-Buonaura, R. Terlizzi, A. Cecere, G. Barletta, P. Cortelli

Research output: Contribution to journalArticlepeer-review


Background: Objective of this study was to evaluate the acute cardiovascular and respiratory effects of switching on the deep brain stimulation in the follow up of nine Parkinson's disease patients with subthalamic nucleus stimulation and six cluster headache patients with posterior hypothalamic area stimulation. Methods: Systolic and diastolic blood pressure, heart rate, and respiratory rate were monitored continuously during supine rest in both groups. Each patient was assessed in two conditions: resting supine with stimulator off and with stimulator on. Results: In supine resting condition switching on the DBS induced no significant changes (p>. 0.05) in systolic and diastolic blood pressure as well as in heart rate and respiratory rate, in both groups of patients, either taking 1. min or 10 heartbeats as a sample for analysis. Conclusions: Switching on the DBS does not modify heart rate, blood pressure nor respiratory rate in both Parkinson and cluster headache patients under resting conditions.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1-2
Publication statusPublished - Jan 26 2012


  • Blood pressure
  • Cardiovascular
  • Cluster
  • Deep brain stimulation
  • Heart rate
  • Parkinson
  • Respiratory

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems


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