SXR rs3842689: A prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome

Stefano Turolo, Alberto Edefonti, Marta Lepore, Luciana Ghio, Eva Cuzzoni, Giuliana Decorti, Andrea Pasini, Marco Materassi, Cristina Malaventura, Fabrizio Pugliese, Giovanni Montini

Research output: Contribution to journalArticle

Abstract

Aim: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. Patients & methods: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. Results: Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. Conclusion: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.

Original languageEnglish
Pages (from-to)1227-1233
Number of pages7
JournalPharmacogenomics
Volume17
Issue number11
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • idiopathic nephrotic syndrome
  • steroid-resistant
  • steroids
  • SXR

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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  • Cite this

    Turolo, S., Edefonti, A., Lepore, M., Ghio, L., Cuzzoni, E., Decorti, G., Pasini, A., Materassi, M., Malaventura, C., Pugliese, F., & Montini, G. (2016). SXR rs3842689: A prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome. Pharmacogenomics, 17(11), 1227-1233. https://doi.org/10.2217/pgs-2016-0029