Symmetrical interdigital hyperkeratosis of the hands: A new case

A. Patrizi, I. Neri, V. Di Lernia, C. Varotti

Research output: Contribution to journalArticlepeer-review


Congenital symmetrical interdigital hyperkeratosis is a rare disorder described by Frei in 1923, characterized by localized hyperkeratosis of the interdigital spaces of the hands and feet. The authors report the case of a 7-year-old girl affected by this condition. The skin hyperkeratotic lesions appeared localized exclusively to the interdigital spaces of the hands. Histologic examination showed orthokeratotic hyperkeratosis, hypergranulosis and acanthosis. Keratolytics failed to improve the clinical picture.

Original languageEnglish
Pages (from-to)459-460
Number of pages2
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - 1993


  • congenital hyperkeratosis
  • interdigital spaces

ASJC Scopus subject areas

  • Dermatology


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