Sympathetic activation in hypertension: What are the effects on vascular, endothelial, and metabolic function?

Research output: Contribution to journalArticle

Abstract

Adrenergic neural function is enhanced in hypertension; it not only influences the development and progression of high blood pressure, but also the occurrence of target organ damage, including cardiac hypertrophy, structural and functional vascular changes, and metabolic abnormalities. This paper will review evidence concerning the importance of sympathetic neural mechanisms in the occurrence of the aforementioned alterations. Particular emphasis will be given to the observed interrelationships in essential hypertension between sympathetic function, arterial stiffness, endothelial function, and insulin resistance. Finally, the therapeutic implications of these findings will be discussed.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalDialogues in Cardiovascular Medicine
Volume12
Issue number3
Publication statusPublished - 2007

Fingerprint

Blood Vessels
Hypertension
Vascular Stiffness
Cardiomegaly
Adrenergic Agents
Insulin Resistance
Therapeutics
Essential Hypertension

Keywords

  • Endothelial function
  • Hypertension
  • Insulin resistance
  • Insulin sensitivity
  • Sympathetic activity
  • Vascular hypertrophy
  • Vascular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Adrenergic neural function is enhanced in hypertension; it not only influences the development and progression of high blood pressure, but also the occurrence of target organ damage, including cardiac hypertrophy, structural and functional vascular changes, and metabolic abnormalities. This paper will review evidence concerning the importance of sympathetic neural mechanisms in the occurrence of the aforementioned alterations. Particular emphasis will be given to the observed interrelationships in essential hypertension between sympathetic function, arterial stiffness, endothelial function, and insulin resistance. Finally, the therapeutic implications of these findings will be discussed.",
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