Sympathetic control of skeletal muscle function: Possible co-operation between noradrenaline and neuropeptide Y in rabbit jaw muscles

C. Grassi, F. Deriu, S. Roatta, R. Santarelli, G. B. Azzena, M. Passatore

Research output: Contribution to journalArticle

Abstract

Stimulation of the cervical sympathetic nerve at 10/s increases by 12.9 ± 0.7% peak tension of maximal twitches in the directly stimulated jaw muscles and markedly depresses (41.6 ± 1.3%) the tonic vibration reflex (TVR) elicited in the same muscles by vibration of the mandible. Both effects are not significantly influenced by administration of β-adrenoceptor antagonists. When both α- and β-adrenergic receptors are blocked, sympathetic stimulation induces a very small increase in twitch tension (3.8 ± 0.7%), while no detectable change in the TVR is observed. Close arterial injection of α1-adrenoceptor agonist phenylephrine mimics the effects induced by sympathetic stimulation on twitch tension and TVR, dose-dependently. The noradrenaline co-transmitter neuropeptide Y also produces a long-lasting, dose-dependent increase in the twitch tension which is unaffected by blockade of adrenergic receptors as well as of the neuromuscular junctions. Contribution of neuropeptide Y to the sympathetically-induced reduction of the stretch reflex is not clearly demonstrated. These data suggest that co-operation between noradrenaline and neuropeptide Y may be effective in determining sympathetic modulation of skeletal muscle function.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalNeuroscience Letters
Volume212
Issue number3
DOIs
Publication statusPublished - Jul 19 1996

Keywords

  • α-Adrenoceptors
  • Jaw muscles
  • Muscle contraction
  • Neuropeptide Y
  • Sympathetic nervous system
  • Tonic vibration reflex

ASJC Scopus subject areas

  • Neuroscience(all)

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