Sympathetic mechanisms, organ damage, and antihypertensive treatment

Guido Grassi, Gino Seravalle, Raffaella Dell'Oro, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Sympathetic activation characterizes essential hypertension, contributing to the development and progression of the high blood pressure state. Throughout the years, evidencehas been accumulated to show that adrenergic overdrive also participates in the pathogenesis of the endorgan damage associated with hypertension, including cardiac hypertrophy, left ventricular diastolic dysfunction, and heart failure, as well as the vascular structural and functional alterations that frequently can be detected in large, medium-size, andsmall arteries. Adrenergic overdrive also participates in the renal insufficiency and failure that may accompany the clinical course of the hypertensive state. This paper review evidence collected over the past few years documenting the importance of neurogenic factors in the development and progression of end-organ damage. The therapeutic implications of this evidence are also highlighted.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalCurrent Hypertension Reports
Issue number4
Publication statusPublished - Aug 2011


  • Antihypertensive treatment
  • Hypertension
  • Sympathetic nervous system
  • Target organ damage

ASJC Scopus subject areas

  • Internal Medicine


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