TY - JOUR
T1 - Sympathetic nerve traffic and baroreflex function in optimal, normal, and high-normal blood pressure states
AU - Seravalle, Gino
AU - Lonati, Laura
AU - Buzzi, Silvia
AU - Cairo, Matteo
AU - Trevano, Fosca Quarti
AU - Dell'Oro, Raffaella
AU - Facchetti, Rita
AU - Mancia, Giuseppe
AU - Grassi, Guido
PY - 2015
Y1 - 2015
N2 - Objective: Adrenergic activation and baroreflex dysfunction are common in established essential hypertension, elderly hypertension, masked and whitecoat hypertension, resistant hypertension, and obesityrelated hypertension. Whether this autonomic behavior is peculiar to established hypertension or is also detectable in the earlier clinical phases of the disease, that is, the highnormal blood pressure (BP) state, is still largely undefined, however. Methods: In 24 individuals with optimal BP (age: 37.1±2.1 years, mean±SEM) and in 27 with normal BP and 38 with high-normal BP, age matched with optimal BP, we measured clinic, 24-h and beat-to-beat BP, heart rate (HR), and muscle sympathetic nerve activity (MSNA) at rest and during baroreceptor stimulation and deactivation. Measurements also included anthropometric as well as echocardiographic and homeostasis model assessment (HOMA) index. Results: For similar anthropometric values, clinic, 24-h ambulatory, and beat-to-beat BPs were significantly greater in normal BP than in optimal BP. This was the case when the high-normal BP group was compared to the normal and optimal BP groups. MSNA (but not HR) was also significantly greater in high-normal BP than in normal BP and optimal BP (51.3±2.0 vs. 40.3±2.3 and 41.1±2.6 bursts per 100 heartbeats, respectively, P
AB - Objective: Adrenergic activation and baroreflex dysfunction are common in established essential hypertension, elderly hypertension, masked and whitecoat hypertension, resistant hypertension, and obesityrelated hypertension. Whether this autonomic behavior is peculiar to established hypertension or is also detectable in the earlier clinical phases of the disease, that is, the highnormal blood pressure (BP) state, is still largely undefined, however. Methods: In 24 individuals with optimal BP (age: 37.1±2.1 years, mean±SEM) and in 27 with normal BP and 38 with high-normal BP, age matched with optimal BP, we measured clinic, 24-h and beat-to-beat BP, heart rate (HR), and muscle sympathetic nerve activity (MSNA) at rest and during baroreceptor stimulation and deactivation. Measurements also included anthropometric as well as echocardiographic and homeostasis model assessment (HOMA) index. Results: For similar anthropometric values, clinic, 24-h ambulatory, and beat-to-beat BPs were significantly greater in normal BP than in optimal BP. This was the case when the high-normal BP group was compared to the normal and optimal BP groups. MSNA (but not HR) was also significantly greater in high-normal BP than in normal BP and optimal BP (51.3±2.0 vs. 40.3±2.3 and 41.1±2.6 bursts per 100 heartbeats, respectively, P
KW - Ambulatory blood pressure
KW - High-normal blood pressure
KW - Insulin resistance
KW - Normal blood pressure
KW - Optimal blood pressure
KW - Sympathetic nerve traffic
UR - http://www.scopus.com/inward/record.url?scp=84942512127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942512127&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000000567
DO - 10.1097/HJH.0000000000000567
M3 - Article
C2 - 25827432
AN - SCOPUS:84942512127
VL - 33
SP - 1411
EP - 1417
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 7
ER -