Sympathetic regulation of vascular function in health and disease

Rosa M. Bruno, Lorenzo Ghiadoni, Gino Seravalle, Raffaella Dell'Oro, Stefano Taddei, Guido Grassi

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions of the cardiovascular system. In the past decades increasing evidence demonstrated that sympathetic neural control is involved not only in the vasomotor control of small resistance arteries but also in modulation of large artery function. Sympathetic activity and vascular function, both of which are key factors in the development and prognosis of cardiovascular events and disease, are linked at several levels. Evidence from experimental studies indicates that the SNS is critically influenced, at the central and also at the peripheral level, by the most relevant factors regulating vascular function, such as nitric oxide (NO), reactive oxygen species (ROS), endothelin (ET), the renin-angiotensin system. Additionally, there is indirect evidence of a reciprocal relationship between endothelial function and activity of the SNS. A number of cardiovascular risk factors and diseases are characterized both by increased sympathetic outflow and decreased endothelial function. In healthy subjects, muscle sympathetic nerve activity (MSNA) appears to be related to surrogate markers of endothelial function, and an acute increase in sympathetic activity has been associated with a decrease in endothelial function in healthy subjects. However, direct evidence of a cause-effect relationship from human studies is scanty. In humans large artery stiffness has been associated with increased sympathetic discharge, both in healthy subjects and in renal transplant recipients. Peripheral sympathetic discharge is also able to modulate wave reflection. On the other hand, large artery stiffness can interfere with autonomic regulation by impairing carotid baroreflex sensitivity.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalFrontiers in Physiology
Volume3 JUL
DOIs
Publication statusPublished - 2012

Fingerprint

Blood Vessels
Sympathetic Nervous System
Arteries
Healthy Volunteers
Health
Baroreflex
Endothelins
Renin-Angiotensin System
Cardiovascular System
Reactive Oxygen Species
Nitric Oxide
Cardiovascular Diseases
Biomarkers
Kidney
Muscles

Keywords

  • Arterialstiffness
  • Endothelium
  • Microneurography
  • Nitricoxide
  • Vascularfunction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sympathetic regulation of vascular function in health and disease. / Bruno, Rosa M.; Ghiadoni, Lorenzo; Seravalle, Gino; Dell'Oro, Raffaella; Taddei, Stefano; Grassi, Guido.

In: Frontiers in Physiology, Vol. 3 JUL, 2012, p. 1-15.

Research output: Contribution to journalArticle

Bruno, Rosa M. ; Ghiadoni, Lorenzo ; Seravalle, Gino ; Dell'Oro, Raffaella ; Taddei, Stefano ; Grassi, Guido. / Sympathetic regulation of vascular function in health and disease. In: Frontiers in Physiology. 2012 ; Vol. 3 JUL. pp. 1-15.
@article{4caa46ed684e4c6dac7ce584b427e7c7,
title = "Sympathetic regulation of vascular function in health and disease",
abstract = "The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions of the cardiovascular system. In the past decades increasing evidence demonstrated that sympathetic neural control is involved not only in the vasomotor control of small resistance arteries but also in modulation of large artery function. Sympathetic activity and vascular function, both of which are key factors in the development and prognosis of cardiovascular events and disease, are linked at several levels. Evidence from experimental studies indicates that the SNS is critically influenced, at the central and also at the peripheral level, by the most relevant factors regulating vascular function, such as nitric oxide (NO), reactive oxygen species (ROS), endothelin (ET), the renin-angiotensin system. Additionally, there is indirect evidence of a reciprocal relationship between endothelial function and activity of the SNS. A number of cardiovascular risk factors and diseases are characterized both by increased sympathetic outflow and decreased endothelial function. In healthy subjects, muscle sympathetic nerve activity (MSNA) appears to be related to surrogate markers of endothelial function, and an acute increase in sympathetic activity has been associated with a decrease in endothelial function in healthy subjects. However, direct evidence of a cause-effect relationship from human studies is scanty. In humans large artery stiffness has been associated with increased sympathetic discharge, both in healthy subjects and in renal transplant recipients. Peripheral sympathetic discharge is also able to modulate wave reflection. On the other hand, large artery stiffness can interfere with autonomic regulation by impairing carotid baroreflex sensitivity.",
keywords = "Arterialstiffness, Endothelium, Microneurography, Nitricoxide, Vascularfunction",
author = "Bruno, {Rosa M.} and Lorenzo Ghiadoni and Gino Seravalle and Raffaella Dell'Oro and Stefano Taddei and Guido Grassi",
year = "2012",
doi = "10.3389/fphys.2012.00284",
language = "English",
volume = "3 JUL",
pages = "1--15",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Sympathetic regulation of vascular function in health and disease

AU - Bruno, Rosa M.

AU - Ghiadoni, Lorenzo

AU - Seravalle, Gino

AU - Dell'Oro, Raffaella

AU - Taddei, Stefano

AU - Grassi, Guido

PY - 2012

Y1 - 2012

N2 - The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions of the cardiovascular system. In the past decades increasing evidence demonstrated that sympathetic neural control is involved not only in the vasomotor control of small resistance arteries but also in modulation of large artery function. Sympathetic activity and vascular function, both of which are key factors in the development and prognosis of cardiovascular events and disease, are linked at several levels. Evidence from experimental studies indicates that the SNS is critically influenced, at the central and also at the peripheral level, by the most relevant factors regulating vascular function, such as nitric oxide (NO), reactive oxygen species (ROS), endothelin (ET), the renin-angiotensin system. Additionally, there is indirect evidence of a reciprocal relationship between endothelial function and activity of the SNS. A number of cardiovascular risk factors and diseases are characterized both by increased sympathetic outflow and decreased endothelial function. In healthy subjects, muscle sympathetic nerve activity (MSNA) appears to be related to surrogate markers of endothelial function, and an acute increase in sympathetic activity has been associated with a decrease in endothelial function in healthy subjects. However, direct evidence of a cause-effect relationship from human studies is scanty. In humans large artery stiffness has been associated with increased sympathetic discharge, both in healthy subjects and in renal transplant recipients. Peripheral sympathetic discharge is also able to modulate wave reflection. On the other hand, large artery stiffness can interfere with autonomic regulation by impairing carotid baroreflex sensitivity.

AB - The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions of the cardiovascular system. In the past decades increasing evidence demonstrated that sympathetic neural control is involved not only in the vasomotor control of small resistance arteries but also in modulation of large artery function. Sympathetic activity and vascular function, both of which are key factors in the development and prognosis of cardiovascular events and disease, are linked at several levels. Evidence from experimental studies indicates that the SNS is critically influenced, at the central and also at the peripheral level, by the most relevant factors regulating vascular function, such as nitric oxide (NO), reactive oxygen species (ROS), endothelin (ET), the renin-angiotensin system. Additionally, there is indirect evidence of a reciprocal relationship between endothelial function and activity of the SNS. A number of cardiovascular risk factors and diseases are characterized both by increased sympathetic outflow and decreased endothelial function. In healthy subjects, muscle sympathetic nerve activity (MSNA) appears to be related to surrogate markers of endothelial function, and an acute increase in sympathetic activity has been associated with a decrease in endothelial function in healthy subjects. However, direct evidence of a cause-effect relationship from human studies is scanty. In humans large artery stiffness has been associated with increased sympathetic discharge, both in healthy subjects and in renal transplant recipients. Peripheral sympathetic discharge is also able to modulate wave reflection. On the other hand, large artery stiffness can interfere with autonomic regulation by impairing carotid baroreflex sensitivity.

KW - Arterialstiffness

KW - Endothelium

KW - Microneurography

KW - Nitricoxide

KW - Vascularfunction

UR - http://www.scopus.com/inward/record.url?scp=84866445127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866445127&partnerID=8YFLogxK

U2 - 10.3389/fphys.2012.00284

DO - 10.3389/fphys.2012.00284

M3 - Article

C2 - 22934037

AN - SCOPUS:84866445127

VL - 3 JUL

SP - 1

EP - 15

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

ER -