TY - JOUR
T1 - Sympathetic response to ventricular extrasystolic beats in hypertension and heart failure
AU - Grassi, Guido
AU - Seravalle, Gino
AU - Bertinieri, Giovanni
AU - Stella, Maria Luisa
AU - Turri, Carlo
AU - Mancia, Giuseppe
PY - 2002
Y1 - 2002
N2 - Provoked premature ventricular contractions (PVCs) evoke, in concomitance with an early and late blood pressure fall and overshoot, an early sympathoexcitation and a later period of sympathoinhibition, respectively. The present study was designed to examine whether in healthy subjects this is the case for spontaneous PVCs. Because of their pathophysiological relevance for arrhythmogenesis, it was also designed to determine whether the sympathetic responses are different from those seen in essential hypertension and congestive heart failure. In 14 untreated mild essential hypertensives (EH; age, 53.8±2.6 years; mean±SEM), 20 untreated congestive heart failure patients (CHF; age, 56.7±2.5 years; New York Heart Association class, II or III), and 16 age-matched healthy subjects (control) in Lown class
AB - Provoked premature ventricular contractions (PVCs) evoke, in concomitance with an early and late blood pressure fall and overshoot, an early sympathoexcitation and a later period of sympathoinhibition, respectively. The present study was designed to examine whether in healthy subjects this is the case for spontaneous PVCs. Because of their pathophysiological relevance for arrhythmogenesis, it was also designed to determine whether the sympathetic responses are different from those seen in essential hypertension and congestive heart failure. In 14 untreated mild essential hypertensives (EH; age, 53.8±2.6 years; mean±SEM), 20 untreated congestive heart failure patients (CHF; age, 56.7±2.5 years; New York Heart Association class, II or III), and 16 age-matched healthy subjects (control) in Lown class
KW - Arrhythmia
KW - Baroreflex
KW - Heart failure
KW - Sympathetic nervous system
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U2 - 10.1161/01.HYP.0000013265.48954.A5
DO - 10.1161/01.HYP.0000013265.48954.A5
M3 - Article
C2 - 11967244
AN - SCOPUS:0036238966
VL - 39
SP - 886
EP - 891
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 4
ER -