Sympathetic response to ventricular extrasystolic beats in hypertension and heart failure

Guido Grassi, Gino Seravalle, Giovanni Bertinieri, Maria Luisa Stella, Carlo Turri, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Provoked premature ventricular contractions (PVCs) evoke, in concomitance with an early and late blood pressure fall and overshoot, an early sympathoexcitation and a later period of sympathoinhibition, respectively. The present study was designed to examine whether in healthy subjects this is the case for spontaneous PVCs. Because of their pathophysiological relevance for arrhythmogenesis, it was also designed to determine whether the sympathetic responses are different from those seen in essential hypertension and congestive heart failure. In 14 untreated mild essential hypertensives (EH; age, 53.8±2.6 years; mean±SEM), 20 untreated congestive heart failure patients (CHF; age, 56.7±2.5 years; New York Heart Association class, II or III), and 16 age-matched healthy subjects (control) in Lown class

Original languageEnglish
Pages (from-to)886-891
Number of pages6
Issue number4
Publication statusPublished - 2002


  • Arrhythmia
  • Baroreflex
  • Heart failure
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine


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