Sympathetic rhythmicity in cardiac transplant recipients

Philippe Van De Borne, Nicola Montano, Krzysztof Narkiewicz, Jean P. Degaute, Ron Oren, Massimo Pagani, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Variability of R-R interval and muscle sympathetic nerve activity (MSNA) occurs predominantly at a low frequency (LF, ±0.1 Hz) and a high frequency (HF, ±0.25 Hz) in normal humans. Increased sympathetic drive in normal humans is associated with an increased LF component of the R-R interval and MSNA. Patients with severe heart failure have high sympathetic activity but decreased or absent LF power of both R-R and MSNA. We tested the hypothesis that this dysfunction in autonomic modulation in heart failure can be reversed by heart transplantation. Methods and Results - We performed spectral analysis of resting MSNA, R-R interval, and respiration in 9 patients with heart transplants, 9 chronic heart failure patients, and 9 normal control subjects, all closely matched for age, sex, and body mass index. MSNA (bursts per minute) was higher in patients with heart transplants (74±3) than either patients with heart failure (56±6) or normal subjects (40±4) (P

Original languageEnglish
Pages (from-to)1606-1610
Number of pages5
JournalCirculation
Volume99
Issue number12
Publication statusPublished - Mar 30 1999

Keywords

  • Heart failure
  • Nervous system
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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