Sympathetic rhythmicity in cardiac transplant recipients

Philippe Van De Borne, Nicola Montano, Krzysztof Narkiewicz, Jean P. Degaute, Ron Oren, Massimo Pagani, Virend K. Somers

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background - Variability of R-R interval and muscle sympathetic nerve activity (MSNA) occurs predominantly at a low frequency (LF, ±0.1 Hz) and a high frequency (HF, ±0.25 Hz) in normal humans. Increased sympathetic drive in normal humans is associated with an increased LF component of the R-R interval and MSNA. Patients with severe heart failure have high sympathetic activity but decreased or absent LF power of both R-R and MSNA. We tested the hypothesis that this dysfunction in autonomic modulation in heart failure can be reversed by heart transplantation. Methods and Results - We performed spectral analysis of resting MSNA, R-R interval, and respiration in 9 patients with heart transplants, 9 chronic heart failure patients, and 9 normal control subjects, all closely matched for age, sex, and body mass index. MSNA (bursts per minute) was higher in patients with heart transplants (74±3) than either patients with heart failure (56±6) or normal subjects (40±4) (P

Original languageEnglish
Pages (from-to)1606-1610
Number of pages5
JournalCirculation
Volume99
Issue number12
Publication statusPublished - Mar 30 1999

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Periodicity
Muscles
Heart Failure
Transplants
Heart Transplantation
Respiration
Body Mass Index
Transplant Recipients

Keywords

  • Heart failure
  • Nervous system
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Van De Borne, P., Montano, N., Narkiewicz, K., Degaute, J. P., Oren, R., Pagani, M., & Somers, V. K. (1999). Sympathetic rhythmicity in cardiac transplant recipients. Circulation, 99(12), 1606-1610.

Sympathetic rhythmicity in cardiac transplant recipients. / Van De Borne, Philippe; Montano, Nicola; Narkiewicz, Krzysztof; Degaute, Jean P.; Oren, Ron; Pagani, Massimo; Somers, Virend K.

In: Circulation, Vol. 99, No. 12, 30.03.1999, p. 1606-1610.

Research output: Contribution to journalArticle

Van De Borne, P, Montano, N, Narkiewicz, K, Degaute, JP, Oren, R, Pagani, M & Somers, VK 1999, 'Sympathetic rhythmicity in cardiac transplant recipients', Circulation, vol. 99, no. 12, pp. 1606-1610.
Van De Borne P, Montano N, Narkiewicz K, Degaute JP, Oren R, Pagani M et al. Sympathetic rhythmicity in cardiac transplant recipients. Circulation. 1999 Mar 30;99(12):1606-1610.
Van De Borne, Philippe ; Montano, Nicola ; Narkiewicz, Krzysztof ; Degaute, Jean P. ; Oren, Ron ; Pagani, Massimo ; Somers, Virend K. / Sympathetic rhythmicity in cardiac transplant recipients. In: Circulation. 1999 ; Vol. 99, No. 12. pp. 1606-1610.
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AU - Van De Borne, Philippe

AU - Montano, Nicola

AU - Narkiewicz, Krzysztof

AU - Degaute, Jean P.

AU - Oren, Ron

AU - Pagani, Massimo

AU - Somers, Virend K.

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N2 - Background - Variability of R-R interval and muscle sympathetic nerve activity (MSNA) occurs predominantly at a low frequency (LF, ±0.1 Hz) and a high frequency (HF, ±0.25 Hz) in normal humans. Increased sympathetic drive in normal humans is associated with an increased LF component of the R-R interval and MSNA. Patients with severe heart failure have high sympathetic activity but decreased or absent LF power of both R-R and MSNA. We tested the hypothesis that this dysfunction in autonomic modulation in heart failure can be reversed by heart transplantation. Methods and Results - We performed spectral analysis of resting MSNA, R-R interval, and respiration in 9 patients with heart transplants, 9 chronic heart failure patients, and 9 normal control subjects, all closely matched for age, sex, and body mass index. MSNA (bursts per minute) was higher in patients with heart transplants (74±3) than either patients with heart failure (56±6) or normal subjects (40±4) (P

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