Sympathetic skin response: Basic mechanisms and clinical applications

Roberto Vetrugno, Rocco Liguori, Pietro Cortelli, Pasquale Montagna

Research output: Contribution to journalArticlepeer-review


Sympathetic skin response (SSR), defined as the momentary change of the electrical potential of the skin, may be spontaneous or reflexively evoked by a variety of internal or by externally applied arousal stimuli. Although the suprasegmental structures influencing the SSR in humans are not well known, SSR has been proposed as a non-invasive approach to investigate the function of the sympathetic system. SSR is easy to apply but current procedures are not sufficiently reliable for diagnostic purposes, and show imperfect correlations both with clinical features and other measurements of autonomic, in particular, sudomotor dysfunction.

Original languageEnglish
Pages (from-to)256-270
Number of pages15
JournalClinical Autonomic Research
Issue number4
Publication statusPublished - Aug 2003


  • Autonomic system
  • Neurophysiology
  • Sudomotor response
  • Sweating
  • Sympathetic skin response

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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