Effetti della stimolazione adrenergica sui sistemi di trasporto transmembrana del Na+ in pazienti con ipertensione essenziale

Translated title of the contribution: Sympathetic stimulation and transmembrane transport of sodium in hypertensive patients

A. Saitta, M. N. Saitta, A. Messina, M. Bonaiuto, M. Cinquegrani, G. Squadrito, M. Castaldo, A. Sardo, E. Imbalzano, F. Squadrito

Research output: Contribution to journalArticle

Abstract

Background. It has been studied whether an adrenergic stimulation induced by the cold pressor test (CPT) could influence the behaviour of the transmembrane transport systems of sodium in hypertensive subjects compared to a normotensive control population. Materials and methods. Twenty-two hypertensive subjects (average age 43.2±5.7 years), with normal weight, without signs of cardiovascular and metabolic diseases, underwent the cold pressor test. The dynamic behaviour of sodium erythrocytic transport systems and plasmatic norepinephrine was evaluated basally, at the third minute during the cold pressor test and 20 minutes after the end of the test. The same test was carried out in a control population made up of 20 normotensive subjects (average age 41.9±4.8 years), selected on the basis of the absence of any cardiovascular or metabolic pathology and without family history of arterial hypertension. Results. The cold pressor test did not cause significant changes in the sodium transmembrane transport systems in normotensive subjects, while in the hypertensive subjects a significant reduction was observed, during the test, in the total efflux of sodium and in the sodium/potassium pump, respectively from 2636±296 μmol/l/red blood cells/hr to 2032±178 μmol/l/red blood cells/hr (p

Translated title of the contributionSympathetic stimulation and transmembrane transport of sodium in hypertensive patients
Original languageItalian
Pages (from-to)275-282
Number of pages8
JournalMinerva Medica
Volume88
Issue number7-8
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

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    Saitta, A., Saitta, M. N., Messina, A., Bonaiuto, M., Cinquegrani, M., Squadrito, G., Castaldo, M., Sardo, A., Imbalzano, E., & Squadrito, F. (1997). Effetti della stimolazione adrenergica sui sistemi di trasporto transmembrana del Na+ in pazienti con ipertensione essenziale. Minerva Medica, 88(7-8), 275-282.