Sympathomoderating influence of benazepril in essential hypertension

Cristina Giannattasio, Bianca M. Cattaneo, Stefano Omboni, Gino Seravalle, Gianbattista Bolla, Lucia Turolo, Alberto Morganti, Guido Grassi, Alberto Zanchetti, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

Objective: In essential hypertension, captopril attenuates forearm vasoconstriction reflexly induced by deactivation of cardiopulmonary and arterial baroreceptors, thus exerting a sympathomoderating effect. We investigated whether this is a common effect of angiotensin converting enzyme (ACE) inhibitors. Methods and design: Cardiopulmonary and arterial baroreceptors were deactivated by progressively reducing central venous pressure (CVP) through progressively greater lower body negative pressures in eight untreated mild essential hypertensives on a moderately low-sodium diet (50mmol/l per day). This deactivation was performed after oral administration of the non-sulphidrylic ACE inhibitor benazepril (10 mg) and placebo according to a double-blind randomized crossover experimental design. Results: After placebo, the reduction in CVP increased forearm vascular resistance (FVR; mean arterial pressure: plethysmographic forearm blood flow ratio). After benazepril, baseline blood pressure (beat-to-beat finger pressure) and FVR were significantly reduced whilst plasma angiotensin II was suppressed and PRA increased (both measured by radioimmunoassay). The FVR increases induced by progressive CVP reduction were less than after placebo administration, and the overall difference was statistically significant. Benazepril did not affect the reflex FVR reduction observed by increasing CVP through leg raising, nor the reflex changes in plasma norepinephrine measured by high-performance liquid chromatography accompanying the changes in FVR. Conclusions: Benazepril attenuates sympathetic vasoconstriction as does captopril. This effect (which is mainly operative during an increased sympathetic drive and exerted through a reduction of adrenoceptor responsiveness) is thus likely to be a class- rather than a compound-related feature.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalJournal of Hypertension
Volume10
Issue number4
Publication statusPublished - 1992

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Keywords

  • Angiotensin converting enzyme inhibitors
  • Angiotensin II
  • Plasma catecholamines
  • Renin-angiotensin system
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Giannattasio, C., Cattaneo, B. M., Omboni, S., Seravalle, G., Bolla, G., Turolo, L., Morganti, A., Grassi, G., Zanchetti, A., & Mancia, G. (1992). Sympathomoderating influence of benazepril in essential hypertension. Journal of Hypertension, 10(4), 373-378.