Sympathovagal imbalance in transsexual subjects

Eugenia Resmini, M. Casu, V. Patrone, A. Rebora, G. Murialdo, F. Minuto, D. Ferone

Research output: Contribution to journalArticlepeer-review


Context: Autonomic nervous system imbalance is related to cardiovascular risk. Heart rate variability (HRV) indexes are associated with age, race, and sex, but the role of sex hormones is still unknown. Objective: To evaluate sympathovagal balance (SB) in transsexuals. Patients: Eighteen transsexual subjects, 12 male-to-female (group 1) and 6 female-to-male (group 2), compared with 34 age-matched controls: 17 males (group 3) and 17 females (group 4). Autonomic testing of SB was performed by Power Spectral Analysis (PSA) of HRV in clinostatism (c) and orthostatism (o). PSA identifies power peaks: high frequency (HF) expresses vagal activity, while low frequency (LF) expresses sympathetic activity. Results: Group 1 showed lower LFc than groups 2, 3, and 4 (p

Original languageEnglish
Pages (from-to)1014-1019
Number of pages6
JournalJournal of Endocrinological Investigation
Issue number11
Publication statusPublished - Nov 2008


  • Heart rate variability
  • Sympathovagal balance
  • Transsexual subjects

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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