Symptomatic intracranial atherosclerotic disease: an ultrasound 2-year follow-up pilot study

Pietro Caliandro, Giuseppe Reale, Andrew M Demchuk, Valeria Caso, Anita Arsovska, Chiara Iacovelli, Silvia Giovannini, Paolo Maria Rossini

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: The objective of this single-center pilot study was to assess if symptomatic intracranial atherosclerotic disease (ICAD) ultrasound features change through the 2 years after acute ischemic stroke or TIA, being ICAD a relevant cause of acute ischemic stroke or TIA, linked to high rates of recurrent stroke.

METHODS: We consecutively enrolled 48 patients with acute ischemic stroke or TIA with symptomatic ICAD detected by transcranial color-coded duplex sonography (TCCS) and confirmed by MR-angiography and/or CT-angiography. We set a neurosonological and clinical follow-up at 3, 6, 12, and 24 months (T0, T1, T2, T3, and T4).

RESULTS: We observed that the hemodynamic effect of the stenosis changed during the 2-year follow-up, as revealed by the modifications of Peak Systolic Velocity (PSV) (Friedman-ANOVA test, p < 0.001). The pairwise post-hoc analysis showed a statistically significant difference between PSV at T0 and PSV at T3 (p = 0.005) and between PSV at T0 and PSV at T4 (p < 0.001) being PSV at T3 and T4 lower than PSV at T0. Seven patients had a new event in the first 12 months.

CONCLUSIONS: The high rate of recurrent stroke or death among ICAD patients seems to be independent of progressive arterial narrowing. A wide multicenter follow-up study is needed in order to identify the factors that, alongside the hemodynamic features, contribute to the high risk of recurrent stroke among patient with symptomatic ICAD.

Original languageEnglish
JournalNeurological Sciences
Publication statusE-pub ahead of print - Jul 9 2018


Dive into the research topics of 'Symptomatic intracranial atherosclerotic disease: an ultrasound 2-year follow-up pilot study'. Together they form a unique fingerprint.

Cite this