Symptomatic psoriatic dactylitis is associated with ultrasound determined extra-synovial inflammatory features and shorter disease duration

Nicolò Girolimetto, Luisa Costa, Luana Mancarella, Olga Addimanda, Paolo Bottiglieri, Francesco Santelli, Riccardo Meliconi, Rosario Peluso, Antonio Del Puente, Pierluigi Macchioni, Carlo Salvarani, Dennis McGonagle, Raffaele Scarpa, Francesco Caso

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To explore the link between ultrasonographic features of dactylitis in psoriatic arthritis (PsA) and symptoms, digital tenderness and duration of dactylitis. Methods: Forty-eight cases of PsA dactylitis were investigated using high frequency ultrasound (US) both in grey scale (GS) and Power Doppler (PD), evaluating the presence and the degree of flexor tenosynovitis, peri-tendinous oedema, subcutaneous PD, extensor tendon involvement, GS synovitis and intra-articular PD signal (PDS) of the involved digits. Patients were compared according to the presence of local pain and digital tenderness, the duration of dactylitis and the concomitant treatment. Results: The presence of pain/tenderness was positively associated with US GS flexor tenosynovitis of grade > 2 (p < 0.001), PD-flexor tenosynovitis (p < 0.001), peri-tendinous oedema (p < 0.001) and subcutaneous PDS (p < 0.001); moreover, it was negatively associated with GS synovitis (p < 0.001) and intra-articular PD (p < 0.001). The same positive and negative association with US findings were found comparing patients with duration of dactylitis shorter or longer than the median (24 weeks) (p < 0.001 for all comparisons). Conclusions: Pain and digital tenderness are linked to dactylitis duration and earlier lesions are associated with extra synovial inflammatory changes. These findings suggest a hitherto unappreciated extra synovial basis for symptoms in PsA dactylitis.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalClinical Rheumatology
DOIs
Publication statusE-pub ahead of print - Dec 19 2018

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Tenosynovitis
Psoriatic Arthritis
Synovitis
Pain
Edema
Joints
Tendons
Power (Psychology)
Therapeutics

Keywords

  • Dactylitis
  • Digital tenderness
  • Flexor
  • Oedema
  • Psoriatic arthritis
  • Tenosynovitis
  • Ultrasound

ASJC Scopus subject areas

  • Rheumatology

Cite this

Symptomatic psoriatic dactylitis is associated with ultrasound determined extra-synovial inflammatory features and shorter disease duration. / Girolimetto, Nicolò; Costa, Luisa; Mancarella, Luana; Addimanda, Olga; Bottiglieri, Paolo; Santelli, Francesco; Meliconi, Riccardo; Peluso, Rosario; Del Puente, Antonio; Macchioni, Pierluigi; Salvarani, Carlo; McGonagle, Dennis; Scarpa, Raffaele; Caso, Francesco.

In: Clinical Rheumatology, 19.12.2018, p. 1-9.

Research output: Contribution to journalArticle

Girolimetto, Nicolò ; Costa, Luisa ; Mancarella, Luana ; Addimanda, Olga ; Bottiglieri, Paolo ; Santelli, Francesco ; Meliconi, Riccardo ; Peluso, Rosario ; Del Puente, Antonio ; Macchioni, Pierluigi ; Salvarani, Carlo ; McGonagle, Dennis ; Scarpa, Raffaele ; Caso, Francesco. / Symptomatic psoriatic dactylitis is associated with ultrasound determined extra-synovial inflammatory features and shorter disease duration. In: Clinical Rheumatology. 2018 ; pp. 1-9.
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abstract = "Objectives: To explore the link between ultrasonographic features of dactylitis in psoriatic arthritis (PsA) and symptoms, digital tenderness and duration of dactylitis. Methods: Forty-eight cases of PsA dactylitis were investigated using high frequency ultrasound (US) both in grey scale (GS) and Power Doppler (PD), evaluating the presence and the degree of flexor tenosynovitis, peri-tendinous oedema, subcutaneous PD, extensor tendon involvement, GS synovitis and intra-articular PD signal (PDS) of the involved digits. Patients were compared according to the presence of local pain and digital tenderness, the duration of dactylitis and the concomitant treatment. Results: The presence of pain/tenderness was positively associated with US GS flexor tenosynovitis of grade > 2 (p < 0.001), PD-flexor tenosynovitis (p < 0.001), peri-tendinous oedema (p < 0.001) and subcutaneous PDS (p < 0.001); moreover, it was negatively associated with GS synovitis (p < 0.001) and intra-articular PD (p < 0.001). The same positive and negative association with US findings were found comparing patients with duration of dactylitis shorter or longer than the median (24 weeks) (p < 0.001 for all comparisons). Conclusions: Pain and digital tenderness are linked to dactylitis duration and earlier lesions are associated with extra synovial inflammatory changes. These findings suggest a hitherto unappreciated extra synovial basis for symptoms in PsA dactylitis.",
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T1 - Symptomatic psoriatic dactylitis is associated with ultrasound determined extra-synovial inflammatory features and shorter disease duration

AU - Girolimetto, Nicolò

AU - Costa, Luisa

AU - Mancarella, Luana

AU - Addimanda, Olga

AU - Bottiglieri, Paolo

AU - Santelli, Francesco

AU - Meliconi, Riccardo

AU - Peluso, Rosario

AU - Del Puente, Antonio

AU - Macchioni, Pierluigi

AU - Salvarani, Carlo

AU - McGonagle, Dennis

AU - Scarpa, Raffaele

AU - Caso, Francesco

PY - 2018/12/19

Y1 - 2018/12/19

N2 - Objectives: To explore the link between ultrasonographic features of dactylitis in psoriatic arthritis (PsA) and symptoms, digital tenderness and duration of dactylitis. Methods: Forty-eight cases of PsA dactylitis were investigated using high frequency ultrasound (US) both in grey scale (GS) and Power Doppler (PD), evaluating the presence and the degree of flexor tenosynovitis, peri-tendinous oedema, subcutaneous PD, extensor tendon involvement, GS synovitis and intra-articular PD signal (PDS) of the involved digits. Patients were compared according to the presence of local pain and digital tenderness, the duration of dactylitis and the concomitant treatment. Results: The presence of pain/tenderness was positively associated with US GS flexor tenosynovitis of grade > 2 (p < 0.001), PD-flexor tenosynovitis (p < 0.001), peri-tendinous oedema (p < 0.001) and subcutaneous PDS (p < 0.001); moreover, it was negatively associated with GS synovitis (p < 0.001) and intra-articular PD (p < 0.001). The same positive and negative association with US findings were found comparing patients with duration of dactylitis shorter or longer than the median (24 weeks) (p < 0.001 for all comparisons). Conclusions: Pain and digital tenderness are linked to dactylitis duration and earlier lesions are associated with extra synovial inflammatory changes. These findings suggest a hitherto unappreciated extra synovial basis for symptoms in PsA dactylitis.

AB - Objectives: To explore the link between ultrasonographic features of dactylitis in psoriatic arthritis (PsA) and symptoms, digital tenderness and duration of dactylitis. Methods: Forty-eight cases of PsA dactylitis were investigated using high frequency ultrasound (US) both in grey scale (GS) and Power Doppler (PD), evaluating the presence and the degree of flexor tenosynovitis, peri-tendinous oedema, subcutaneous PD, extensor tendon involvement, GS synovitis and intra-articular PD signal (PDS) of the involved digits. Patients were compared according to the presence of local pain and digital tenderness, the duration of dactylitis and the concomitant treatment. Results: The presence of pain/tenderness was positively associated with US GS flexor tenosynovitis of grade > 2 (p < 0.001), PD-flexor tenosynovitis (p < 0.001), peri-tendinous oedema (p < 0.001) and subcutaneous PDS (p < 0.001); moreover, it was negatively associated with GS synovitis (p < 0.001) and intra-articular PD (p < 0.001). The same positive and negative association with US findings were found comparing patients with duration of dactylitis shorter or longer than the median (24 weeks) (p < 0.001 for all comparisons). Conclusions: Pain and digital tenderness are linked to dactylitis duration and earlier lesions are associated with extra synovial inflammatory changes. These findings suggest a hitherto unappreciated extra synovial basis for symptoms in PsA dactylitis.

KW - Dactylitis

KW - Digital tenderness

KW - Flexor

KW - Oedema

KW - Psoriatic arthritis

KW - Tenosynovitis

KW - Ultrasound

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