Symptoms of inherited factor V deficiency in 35 Iranian patients

M. Lak, R. Sharifian, F. Peyvandi, P. M. Mannucci

Research output: Contribution to journalArticle


The type of bleeding symptom has been evaluated in 35 Iranian patients with an inherited deficiency of factor V, with plasma levels between 1% and 10%. The most frequent symptoms included epistaxis and excessive bleeding after surgery. Haemarthroses and muscle haematomas were less common, even in severely deficient patients. More severe symptoms such as gastrointestinal and central nervous system bleeding were rare. The severity of bleeding symptoms was only partially related to the degree of factor V deficiency in plasma. On the whole, human factor V deficiency is characterized by a moderately severe bleeding phenotype.

Original languageEnglish
Pages (from-to)1067-1069
Number of pages3
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 1998


  • Bleeding symptoms
  • Factor V deficiency
  • Inherited coagulation disorders

ASJC Scopus subject areas

  • Hematology

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