Synapsin I, a neuron-specific phosphoprotein interacting with small synaptic vesicles and F-actin

Fabio Benfenati, Flavia Valtorta, Martin Bähler, Paul Greengard

Research output: Contribution to journalArticle

Abstract

Synapsin I is a neuron-specific phosphoprotein which is a substrate for cAMP- and Ca2+/calmodulin-dependent protein kinases. It is specifically localized to the cytoplasmic side of small synaptic vesicles. The interaction of synapsin I with the synaptic vesicle membrane is complex in nature, since it is modulated by phosphorylation and involves binding of different domains of the molecule to phospholipid and protein components of synaptic vesicles. Synapsin I is also able to interact with actin filaments in a phosphorylation-dependent manner. Because of these properties, it has been hypothesized that synapsin I acts as a dynamic link between synaptic vesicles an the actin meshwork of the nerve terminal, thereby modulating the release of neurotransmitter.

Original languageEnglish
Pages (from-to)1007-1021
Number of pages15
JournalCell Biology International Reports
Volume13
Issue number12
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cell Biology

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