Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris

Federica Maiole, Giulia Tedeschi, Simona Candiani, Luca Maragliano, Fabio Benfenati, Letizia Zullo

Research output: Contribution to journalArticle

Abstract

Synapsins are a family of phosphoproteins fundamental to the regulation of neurotransmitter release. They are typically neuron-specific, although recent evidence pointed to their expression in non-neuronal cells where they play a role in exocytosis and vesicle trafficking. In this work, we characterized synapsin transcripts in the invertebrate mollusk Octopus vulgaris and present evidence of their expression not only in the brain but also in male and female reproductive organs. We identified three synapsin isoforms phylogenetically correlated to that of other invertebrates and with a modular structure characteristic of mammalian synapsins with a central, highly conserved C domain, important for the protein functions, and less conserved A, B and E domains. Our molecular modeling analysis further provided a solid background for predicting synapsin functional binding to ATP, actin filaments and secretory vesicles. Interestingly, we found that synapsin expression in ovary and testis increased during sexual maturation in cells with a known secretory role, potentially matching the occurrence of a secretion process. This might indicate that its secretory role has evolved across animals according to cell activity in spite of cell identity. We believe that this study may yield insights into the convergent evolution of ubiquitously expressed proteins between vertebrates and invertebrates.

Original languageEnglish
Article number15430
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Synapsins
Octopodiformes
Invertebrates
Sexual Maturation
Mollusca
Secretory Pathway
Phosphoproteins
Exocytosis
Secretory Vesicles
Actin Cytoskeleton
Neurotransmitter Agents
Vertebrates
Testis
Ovary
Protein Isoforms
Neurons
Brain

ASJC Scopus subject areas

  • General

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Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris. / Maiole, Federica; Tedeschi, Giulia; Candiani, Simona; Maragliano, Luca; Benfenati, Fabio; Zullo, Letizia.

In: Scientific Reports, Vol. 9, No. 1, 15430, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Zullo, Letizia

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