Synaptic and mitochondrial morphometry provides structural correlates of successful brain aging

Carlo Bertoni-Freddari, Patrizia Fattoretti, Belinda Giorgetti, Yessica Grossi, Marta Balietti, Tiziana Casoli, Giuseppina Di Stefano, Gemma Perretta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Average synaptic size (S), synaptic numeric density (Nv) and surface density (Sv), average mitochondrial volume, mitochondrial numeric density, and mitochondrial volume density were measured by morphometry in the frontal (FC) and temporal (TC) cortex from adult and oldmonkeys (Macaca fascicularis). In relation to aging, Sv did not change, while Nv was significantly decreased in TC, but not in FC. S was significantly increased in FC and TC. No significant difference due to age was found with regard to mitochondrial ultrastructure. Considering the functional significance of the above parameters, their substantial agerelated constancy suggests that theymay reasonably represent structural correlates of successful brain aging.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages51-53
Number of pages3
Volume1097
DOIs
Publication statusPublished - Feb 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1097
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Age-related synaptic deterioration
  • Macaca fascicularis
  • Mitochondrial morphometry
  • Mitochondrial structural dynamics
  • Mitochondrial volume homeostasis
  • Synaptic mitochondria
  • Synaptic morphometry
  • Synaptic pathology
  • Synaptic plasticity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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