Synaptic dysfunction in Alzheimer's disease

Elena Marcello, Roberta Epis, Claudia Saraceno, Monica Di Luca

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Generation of amyloid peptide (Aβ) is at the beginning of a cascade that leads to Alzheimer's disease (AD). Amyloid precursor protein (APP), as well as β- and γ-secretases, is the principal player involved in Aβ production, while α-secretase cleavage on APP prevents Aβ deposition. Recent studies suggested that soluble assembly states of Aβ peptides can cause cognitive problems by disrupting synaptic function in the absence of significant neurodegeneration. Therefore, current research investigates the relative importance of these various soluble Aβ assemblies in causing synaptic dysfunction and cognitive deficits. Several Aβ oligomers targets and cellular mechanisms responsible of Aβ-induced synaptic failure have been identified. The first and most important mechanism impugns a toxic gain of function for Aβ which results due to self-association and attainment of new structures capable of novel interactions that lead to impaired plasticity. Other scenarios predicate that Aβ has a normal physiological role. On the one hand, insufficient Aβ could lead to a loss of normal function, whereas excess Aβ may precipitate dysfunction. How this occurs and which the main target/s is/are for the synaptic action of Aβ remains to be fully understood and would certainly represent one of the main challenges to future AD research.

Original languageEnglish
Title of host publicationSynaptic Plasticity: Dynamics, Development and Disease
Pages573-601
Number of pages29
Volume970
DOIs
Publication statusPublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume970
ISSN (Print)00652598

Keywords

  • Alzheimer's disease
  • Amyloid ß
  • Amyloid Precursor Protein
  • Glutamate receptors
  • Secretases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Synaptic dysfunction in Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this

    Marcello, E., Epis, R., Saraceno, C., & Di Luca, M. (2012). Synaptic dysfunction in Alzheimer's disease. In Synaptic Plasticity: Dynamics, Development and Disease (Vol. 970, pp. 573-601). (Advances in Experimental Medicine and Biology; Vol. 970). https://doi.org/10.1007/978-3-7091-0932-8_25