Synaptic plasticity and experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Massimiliano Di Filippo, Antonio De Iure, Valentina Durante, Lorenzo Gaetani, Andrea Mancini, Paola Sarchielli, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

Structural and functional neuronal plasticity could play a crucial role during the course of multiple sclerosis (MS). The immune system and the central nervous system (CNS) strictly interact in physiologic conditions and during inflammation to modulate neuroplasticity and in particular the ability of the synapses to undergo long-term changes in the efficacy of synaptic transmission, such as long-term potentiation (LTP). During MS, neuro-inflammation might deeply influence the ability of neuronal networks to express physiologic plasticity, reducing the plastic reserve of the brain, with a negative impact on symptoms progression and cognitive performances. In this manuscript we review the evidence on synaptic plasticity alterations in experimental autoimmune encephalomyelitis (EAE), the most diffuse and widely utilized experimental model of MS, together with their potential underlying mechanisms and clinical relevance.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalBrain Research
Volume1621
DOIs
Publication statusPublished - Sep 24 2015

Keywords

  • EAE
  • LTD
  • LTP
  • Multiple sclerosis
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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