Synaptic potentiation induced by rTMS: Effect of lidocaine infusion

M. Inghilleri, A. Conte, V. Frasca, F. Gilio, C. Lorenzano, A. Berardelli

Research output: Contribution to journalArticle

Abstract

Repetitive transcranial magnetic stimulation (rTMS) delivered at various intensities and frequencies excites cortical motor areas. Trains of stimuli (at 5-Hz frequency, and suprathreshold intensity) progressively increase the size of motor evoked potentials (MEPs) and the duration of the cortical silent period (CSP) in normal subjects. Because antiepileptic drugs, acting mainly on sodium channels, depress MEP facilitation during rTMS, we suggested that rTMS trains facilitate the MEP size by inducing synaptic potentiation primarily involving voltage-gated sodium channels. The aim of this study was to evaluate the effect of lidocaine - a drug that acts selectively on sodium channels - on the rTMS-induced changes in cortical excitability. We tested the changes in motor threshold, MEP size, CSP duration evoked by focal rTMS and the M-wave amplitude in healthy subjects before and after lidocaine infusion. Lidocaine abolished the normal rTMS-induced facilitation of MEPs but left the other rTMS variables and the M-wave unchanged. Our results suggest that the MEP facilitation related to rTMS-induced synaptic potentiation results from an increase in cortical excitatory interneuron excitability that involves voltage-gated sodium channels.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalExperimental Brain Research
Volume163
Issue number1
DOIs
Publication statusPublished - May 2005

Fingerprint

Transcranial Magnetic Stimulation
Lidocaine
Motor Evoked Potentials
Voltage-Gated Sodium Channels
Sodium Channels
Motor Cortex
Interneurons
Anticonvulsants
Healthy Volunteers
Pharmaceutical Preparations

Keywords

  • Cortical excitability
  • MEP
  • Sodium channels
  • Synaptic potentiation
  • Transcranial stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Synaptic potentiation induced by rTMS : Effect of lidocaine infusion. / Inghilleri, M.; Conte, A.; Frasca, V.; Gilio, F.; Lorenzano, C.; Berardelli, A.

In: Experimental Brain Research, Vol. 163, No. 1, 05.2005, p. 114-117.

Research output: Contribution to journalArticle

Inghilleri, M. ; Conte, A. ; Frasca, V. ; Gilio, F. ; Lorenzano, C. ; Berardelli, A. / Synaptic potentiation induced by rTMS : Effect of lidocaine infusion. In: Experimental Brain Research. 2005 ; Vol. 163, No. 1. pp. 114-117.
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