Synaptic synthesis, dephosphorylation, and degradation: A novel paradigm for an activity-dependent neuronal control of CDKL5

Paolo La Montanara, Laura Rusconi, Albina Locarno, Lia Forti, Isabella Barbiero, Marco Tramarin, Chetan Chandola, Charlotte Kilstrup-Nielsen, Nicoletta Landsberger

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although associated with intellectual disability, CDKL5 functions and regulation are poorly understood. Results: Upon neuronal activation, CDKL5 is dynamically regulated through local synthesis, dephosphorylation, and degradation. Conclusion: Neuronal activity and maturation control CDKL5 phosphorylation state and expression. Significance: This is the first report showing the activity-dependent modulation of CDKL5 in the neuronal periphery, further linking it to synapse development and plasticity.

Original languageEnglish
Pages (from-to)4512-4527
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
Publication statusPublished - Feb 13 2015

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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