TY - JOUR
T1 - Synaptic synthesis, dephosphorylation, and degradation
T2 - A novel paradigm for an activity-dependent neuronal control of CDKL5
AU - La Montanara, Paolo
AU - Rusconi, Laura
AU - Locarno, Albina
AU - Forti, Lia
AU - Barbiero, Isabella
AU - Tramarin, Marco
AU - Chandola, Chetan
AU - Kilstrup-Nielsen, Charlotte
AU - Landsberger, Nicoletta
PY - 2015/2/13
Y1 - 2015/2/13
N2 - Background: Although associated with intellectual disability, CDKL5 functions and regulation are poorly understood. Results: Upon neuronal activation, CDKL5 is dynamically regulated through local synthesis, dephosphorylation, and degradation. Conclusion: Neuronal activity and maturation control CDKL5 phosphorylation state and expression. Significance: This is the first report showing the activity-dependent modulation of CDKL5 in the neuronal periphery, further linking it to synapse development and plasticity.
AB - Background: Although associated with intellectual disability, CDKL5 functions and regulation are poorly understood. Results: Upon neuronal activation, CDKL5 is dynamically regulated through local synthesis, dephosphorylation, and degradation. Conclusion: Neuronal activity and maturation control CDKL5 phosphorylation state and expression. Significance: This is the first report showing the activity-dependent modulation of CDKL5 in the neuronal periphery, further linking it to synapse development and plasticity.
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U2 - 10.1074/jbc.M114.589762
DO - 10.1074/jbc.M114.589762
M3 - Article
C2 - 25555910
AN - SCOPUS:84922812800
VL - 290
SP - 4512
EP - 4527
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 7
ER -