Abstract
In the present investigation we studied the synaptosomal uptake of glutamate in brain omogenate of Mongolian gerbils submitted to bilateral common carotid occlusion, with and without subsequent return of blood flow. The results show that glutamate uptake after ischemia is reduced by about 35% The damage appears to be persistent, since return of blood flow restores uptake only slightly. The membrane alterations occurring in ischemia could explain the persistence of glutamate transporter impairment. Besides the blockade of NMDA receptors, the stimulation and/or the protection of the uptake systems for glutamate could be of help in preventing neuronal ischemic damage.
| Original language | English |
|---|---|
| Pages (from-to) | 195-199 |
| Number of pages | 5 |
| Journal | Neurochemical Research |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1995 |
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Keywords
- Cerebral ischemia
- glutamate transport
- synaptosomal uptake
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry
Cite this
Synaptosomal glutamate uptake in a model of experimental cerebral ischemia. / Zanchin, G.; De Boni, A.; Lauria, G.; Maggioni, F.; Rossi, P.; Villacara, A.
In: Neurochemical Research, Vol. 20, No. 2, 02.1995, p. 195-199.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synaptosomal glutamate uptake in a model of experimental cerebral ischemia
AU - Zanchin, G.
AU - De Boni, A.
AU - Lauria, G.
AU - Maggioni, F.
AU - Rossi, P.
AU - Villacara, A.
PY - 1995/2
Y1 - 1995/2
N2 - In the present investigation we studied the synaptosomal uptake of glutamate in brain omogenate of Mongolian gerbils submitted to bilateral common carotid occlusion, with and without subsequent return of blood flow. The results show that glutamate uptake after ischemia is reduced by about 35% The damage appears to be persistent, since return of blood flow restores uptake only slightly. The membrane alterations occurring in ischemia could explain the persistence of glutamate transporter impairment. Besides the blockade of NMDA receptors, the stimulation and/or the protection of the uptake systems for glutamate could be of help in preventing neuronal ischemic damage.
AB - In the present investigation we studied the synaptosomal uptake of glutamate in brain omogenate of Mongolian gerbils submitted to bilateral common carotid occlusion, with and without subsequent return of blood flow. The results show that glutamate uptake after ischemia is reduced by about 35% The damage appears to be persistent, since return of blood flow restores uptake only slightly. The membrane alterations occurring in ischemia could explain the persistence of glutamate transporter impairment. Besides the blockade of NMDA receptors, the stimulation and/or the protection of the uptake systems for glutamate could be of help in preventing neuronal ischemic damage.
KW - Cerebral ischemia
KW - glutamate transport
KW - synaptosomal uptake
UR - http://www.scopus.com/inward/record.url?scp=0028943983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028943983&partnerID=8YFLogxK
U2 - 10.1007/BF00970544
DO - 10.1007/BF00970544
M3 - Article
VL - 20
SP - 195
EP - 199
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 2
ER -