Synchronous colorectal liver metastases

Research output: Chapter in Book/Report/Conference proceedingChapter


Radical surgery is the gold standard in the treatment of synchronous colorectal liver metastases. It prolongs patient survival and is potentially curative in some cases. Simultaneous colorectal and liver resection can be safely performed if minor hepatectomy is planned, whereas for major hepatectomy the results of simultaneous resection are controversial. Neoadjuvant chemotherapy helps to better select candidates for surgery, but there is no evidence in favour of its systematic application. In selected patients, such as those with more than three metastases, neoadjuvant chemotherapy may be beneficial. In patients with unresectable synchronous liver metastases, chemotherapy is the treatment of choice. In asymptomatic patients, chemotherapy should be immediately started with the primary tumor still in place. The risk of occlusion is low, especially if modern chemotherapy regimens are administered. In case of symptomatic primary tumor, chemotherapy must be preceded by symptoms treatment. Endoscopic metallic stents may represent an effective alternative to surgery in the treatment of occlusive symptoms. A multidisciplinary approach is mandatory in patients with primary colorectal cancer and synchronous liver metastases in order to define the optimal treatment strategy, which must be tailored to every single patient.

Original languageEnglish
Title of host publicationSurgical Treatment of Colorectal Liver Metastases
PublisherSpringer Milan
Number of pages19
ISBN (Print)9788847018082
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Medicine(all)

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    Viganò, L. (2011). Synchronous colorectal liver metastases. In Surgical Treatment of Colorectal Liver Metastases (pp. 101-119). Springer Milan.