Synchronous lung cancers: When same histological types feature different molecular profiles and response phenotypes

Giulia M. Stella, Francesca Cemmi, Simona Inghilleri, Michele Zorzetto, Maurizio Luisetti, Ernesto Pozzi

Research output: Contribution to journalArticlepeer-review

Abstract

We discuss the case of synchronous bilateral lung cancers which feature the same histological phenotype and a different EGFR mutational profile. Both histological and molecular characterizations were performed on specimens derived thorough CT-guided fine needle aspiration. A first-line chemotherapy was unsuccessful. Subsequent objective response to the EGFR inhibitor Erlotinib was clearly coherent with the sequencing data and the mutated nodule was effectively reduced (> 50%) after therapy, while the lesion assessed as EGFR wild type featured a slight response. This report has two relevant implications. It points out that in case of multiple malignant lesions at time of diagnosis, molecular profiling should be as extensive as possible and it might contribute to clarify the association between the lesions found. Besides the molecular analysis on cytology specimens could identify an accurate and safe diagnostic approach for clinical use.

Original languageEnglish
Pages (from-to)474-477
Number of pages4
JournalJournal of Cancer
Volume2
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Synchronous bilateral lung cancer

ASJC Scopus subject areas

  • Oncology

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