Abstract
Mammary analogue secretory carcinoma (MASC) is a recently described low-grade salivary gland malignancy with histologic, immunohistochemical and molecular similarities to secretory carcinoma of the breast, including a specific t(12;15)(p13;q25) resulting in an ETV6–NTRK3 gene fusion. Ultrasound and magnetic resonance imaging frequently document a macrocystic structure. The main differential diagnosis of secretory carcinoma is with low grade acinic cell carcinoma (AciCC). The two can be differentiated with immunohistochemical stains for S100, mammaglobin, carbonic anhydrase VI and DOG-1; the identification of the specific translocation can help to characterize non-typical cases. We report a unique case of synchronous MASC and AciCC presenting in a parotid gland and discuss the implications of the correct identification of the two tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Head and Neck Pathology |
| DOIs | |
| Publication status | Accepted/In press - Jun 6 2018 |
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Keywords
- Acinic cell carcinoma
- Cystic carcinoma
- MASC
- Parotid
- Salivary gland tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology
Cite this
Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma : Report of a Case. / Mossinelli, C.; Pigni, C.; Sovardi, F.; Occhini, A.; Preda, L.; Benazzo, M.; Morbini, P.; Pagella, F.
In: Head and Neck Pathology, 06.06.2018, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma
T2 - Report of a Case
AU - Mossinelli, C.
AU - Pigni, C.
AU - Sovardi, F.
AU - Occhini, A.
AU - Preda, L.
AU - Benazzo, M.
AU - Morbini, P.
AU - Pagella, F.
PY - 2018/6/6
Y1 - 2018/6/6
N2 - Mammary analogue secretory carcinoma (MASC) is a recently described low-grade salivary gland malignancy with histologic, immunohistochemical and molecular similarities to secretory carcinoma of the breast, including a specific t(12;15)(p13;q25) resulting in an ETV6–NTRK3 gene fusion. Ultrasound and magnetic resonance imaging frequently document a macrocystic structure. The main differential diagnosis of secretory carcinoma is with low grade acinic cell carcinoma (AciCC). The two can be differentiated with immunohistochemical stains for S100, mammaglobin, carbonic anhydrase VI and DOG-1; the identification of the specific translocation can help to characterize non-typical cases. We report a unique case of synchronous MASC and AciCC presenting in a parotid gland and discuss the implications of the correct identification of the two tumors.
AB - Mammary analogue secretory carcinoma (MASC) is a recently described low-grade salivary gland malignancy with histologic, immunohistochemical and molecular similarities to secretory carcinoma of the breast, including a specific t(12;15)(p13;q25) resulting in an ETV6–NTRK3 gene fusion. Ultrasound and magnetic resonance imaging frequently document a macrocystic structure. The main differential diagnosis of secretory carcinoma is with low grade acinic cell carcinoma (AciCC). The two can be differentiated with immunohistochemical stains for S100, mammaglobin, carbonic anhydrase VI and DOG-1; the identification of the specific translocation can help to characterize non-typical cases. We report a unique case of synchronous MASC and AciCC presenting in a parotid gland and discuss the implications of the correct identification of the two tumors.
KW - Acinic cell carcinoma
KW - Cystic carcinoma
KW - MASC
KW - Parotid
KW - Salivary gland tumor
UR - http://www.scopus.com/inward/record.url?scp=85048045607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048045607&partnerID=8YFLogxK
U2 - 10.1007/s12105-018-0935-1
DO - 10.1007/s12105-018-0935-1
M3 - Article
AN - SCOPUS:85048045607
SP - 1
EP - 6
JO - Head and Neck Pathology
JF - Head and Neck Pathology
SN - 1936-055X
ER -