Abstract
The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 2484-2489 |
| Number of pages | 6 |
| Journal | International Journal of Clinical and Experimental Pathology |
| Volume | 7 |
| Issue number | 5 |
| Publication status | Published - 2014 |
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Keywords
- EGFR
- Mesothelioma
- Peritoneal malignancy
- Pleural malignancy
- X-chromosome inactivation
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Medicine(all)
Cite this
Synchronous pleural and peritoneal malignant mesothelioma : A case report and review of literature. / Del Gobbo, Alessandro; Fiori, Stefano; Gaudioso, Gabriella; Bonaparte, Eleonora; Tabano, Silvia; Palleschi, Alessandro; Bosari, Silvano; Ferrero, Stefano.
In: International Journal of Clinical and Experimental Pathology, Vol. 7, No. 5, 2014, p. 2484-2489.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synchronous pleural and peritoneal malignant mesothelioma
T2 - A case report and review of literature
AU - Del Gobbo, Alessandro
AU - Fiori, Stefano
AU - Gaudioso, Gabriella
AU - Bonaparte, Eleonora
AU - Tabano, Silvia
AU - Palleschi, Alessandro
AU - Bosari, Silvano
AU - Ferrero, Stefano
PY - 2014
Y1 - 2014
N2 - The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
AB - The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
KW - EGFR
KW - Mesothelioma
KW - Peritoneal malignancy
KW - Pleural malignancy
KW - X-chromosome inactivation
UR - http://www.scopus.com/inward/record.url?scp=84902465616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902465616&partnerID=8YFLogxK
M3 - Article
C2 - 24966960
AN - SCOPUS:84902465616
VL - 7
SP - 2484
EP - 2489
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
SN - 1936-2625
IS - 5
ER -