Synchronous pleural and peritoneal malignant mesothelioma: A case report and review of literature

Alessandro Del Gobbo, Stefano Fiori, Gabriella Gaudioso, Eleonora Bonaparte, Silvia Tabano, Alessandro Palleschi, Silvano Bosari, Stefano Ferrero

Research output: Contribution to journalArticlepeer-review


The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.

Original languageEnglish
Pages (from-to)2484-2489
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Issue number5
Publication statusPublished - 2014


  • EGFR
  • Mesothelioma
  • Peritoneal malignancy
  • Pleural malignancy
  • X-chromosome inactivation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medicine(all)


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