Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer

Anna Pozza, Cesare Ruffolo, Alain Fiorot, Luigi Padoan, Francesca Erroi, Marco Massani, Ezio Caratozzolo, Luca Bonariol, Francesco Ferrara, Lorenzo Norberto, Carlo Castoro, Nicolò Bassi, Marco Scarpa

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The principal aim of endoscopic follow-up programs after curative resection of colorectal cancer (CRC) is to improve survival and identify local recurrence and metachronous CRC. The aim of our study was to identify the possible predictors of metachronous colorectal lesions.

METHODS: The records of 348 consecutive patients with CRC and who completed at least 1 year of endoscopic follow-up after surgery were analyzed. In this group, 336 patients underwent surgery for primitive CRC and 12 for metachronous cancer. Patients' characteristics, operative details, and endoscopical follow-up findings were retrieved. Multivariate survival analyses were used to identify patient categories at risk of metachronous colonic lesions.

RESULTS: 128 patients presented a metachronous lesion: 118 adenomas and 10 adenocarcinomas. At multivariate analysis, active smoke (HR = 1.84, p = 0.03), neoadjuvant therapy (HR = 0.24, p = 0.01), and presence of synchronous polyps (HR = 1.55, p = 0.04) resulted independent predictors of metachronous adenoma after CRC removal while neoadjuvant therapy (HR = 0.25, p = 0.02), active smoke (HR = 1.54, p = 0.04), and presence of synchronous polyps (HR = 1.86, p = 0.02) resulted independent predictors of metachronous lesions after CRC removal.

CONCLUSIONS: This study demonstrated a high rate of metachronous lesions in the early follow-up after curative CRC resection. The negative effects of synchronous polyps should be carefully evaluated when planning patients' follow-up.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalActa Chirurgica Belgica
Volume116
Issue number4
DOIs
Publication statusPublished - Aug 2016

Fingerprint

Polyps
Colorectal Neoplasms
Neoadjuvant Therapy
Smoke
Adenoma
Multivariate Analysis
Survival Analysis
Adenocarcinoma
Recurrence
Survival
Neoplasms

Keywords

  • Adenocarcinoma
  • Adult
  • Aged
  • Colectomy
  • Colonoscopy
  • Colorectal Neoplasms
  • Databases, Factual
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Recurrence, Local
  • Neoplasms, Multiple Primary
  • Neoplasms, Second Primary
  • Polyps
  • Retrospective Studies
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome
  • Journal Article
  • Multicenter Study

Cite this

Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer. / Pozza, Anna; Ruffolo, Cesare; Fiorot, Alain; Padoan, Luigi; Erroi, Francesca; Massani, Marco; Caratozzolo, Ezio; Bonariol, Luca; Ferrara, Francesco; Norberto, Lorenzo; Castoro, Carlo; Bassi, Nicolò; Scarpa, Marco.

In: Acta Chirurgica Belgica, Vol. 116, No. 4, 08.2016, p. 225-230.

Research output: Contribution to journalArticle

Pozza, A, Ruffolo, C, Fiorot, A, Padoan, L, Erroi, F, Massani, M, Caratozzolo, E, Bonariol, L, Ferrara, F, Norberto, L, Castoro, C, Bassi, N & Scarpa, M 2016, 'Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer', Acta Chirurgica Belgica, vol. 116, no. 4, pp. 225-230. https://doi.org/10.1080/00015458.2016.1171075
Pozza, Anna ; Ruffolo, Cesare ; Fiorot, Alain ; Padoan, Luigi ; Erroi, Francesca ; Massani, Marco ; Caratozzolo, Ezio ; Bonariol, Luca ; Ferrara, Francesco ; Norberto, Lorenzo ; Castoro, Carlo ; Bassi, Nicolò ; Scarpa, Marco. / Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer. In: Acta Chirurgica Belgica. 2016 ; Vol. 116, No. 4. pp. 225-230.
@article{04004bc8c8e24286a9250a0af123cf36,
title = "Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer",
abstract = "BACKGROUND: The principal aim of endoscopic follow-up programs after curative resection of colorectal cancer (CRC) is to improve survival and identify local recurrence and metachronous CRC. The aim of our study was to identify the possible predictors of metachronous colorectal lesions.METHODS: The records of 348 consecutive patients with CRC and who completed at least 1 year of endoscopic follow-up after surgery were analyzed. In this group, 336 patients underwent surgery for primitive CRC and 12 for metachronous cancer. Patients' characteristics, operative details, and endoscopical follow-up findings were retrieved. Multivariate survival analyses were used to identify patient categories at risk of metachronous colonic lesions.RESULTS: 128 patients presented a metachronous lesion: 118 adenomas and 10 adenocarcinomas. At multivariate analysis, active smoke (HR = 1.84, p = 0.03), neoadjuvant therapy (HR = 0.24, p = 0.01), and presence of synchronous polyps (HR = 1.55, p = 0.04) resulted independent predictors of metachronous adenoma after CRC removal while neoadjuvant therapy (HR = 0.25, p = 0.02), active smoke (HR = 1.54, p = 0.04), and presence of synchronous polyps (HR = 1.86, p = 0.02) resulted independent predictors of metachronous lesions after CRC removal.CONCLUSIONS: This study demonstrated a high rate of metachronous lesions in the early follow-up after curative CRC resection. The negative effects of synchronous polyps should be carefully evaluated when planning patients' follow-up.",
keywords = "Adenocarcinoma, Adult, Aged, Colectomy, Colonoscopy, Colorectal Neoplasms, Databases, Factual, Disease-Free Survival, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Neoplasms, Multiple Primary, Neoplasms, Second Primary, Polyps, Retrospective Studies, Risk Assessment, Survival Analysis, Treatment Outcome, Journal Article, Multicenter Study",
author = "Anna Pozza and Cesare Ruffolo and Alain Fiorot and Luigi Padoan and Francesca Erroi and Marco Massani and Ezio Caratozzolo and Luca Bonariol and Francesco Ferrara and Lorenzo Norberto and Carlo Castoro and Nicol{\`o} Bassi and Marco Scarpa",
year = "2016",
month = "8",
doi = "10.1080/00015458.2016.1171075",
language = "English",
volume = "116",
pages = "225--230",
journal = "Acta Chirurgica Belgica",
issn = "0001-5458",
publisher = "ARSMB-KVBMG",
number = "4",

}

TY - JOUR

T1 - Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer

AU - Pozza, Anna

AU - Ruffolo, Cesare

AU - Fiorot, Alain

AU - Padoan, Luigi

AU - Erroi, Francesca

AU - Massani, Marco

AU - Caratozzolo, Ezio

AU - Bonariol, Luca

AU - Ferrara, Francesco

AU - Norberto, Lorenzo

AU - Castoro, Carlo

AU - Bassi, Nicolò

AU - Scarpa, Marco

PY - 2016/8

Y1 - 2016/8

N2 - BACKGROUND: The principal aim of endoscopic follow-up programs after curative resection of colorectal cancer (CRC) is to improve survival and identify local recurrence and metachronous CRC. The aim of our study was to identify the possible predictors of metachronous colorectal lesions.METHODS: The records of 348 consecutive patients with CRC and who completed at least 1 year of endoscopic follow-up after surgery were analyzed. In this group, 336 patients underwent surgery for primitive CRC and 12 for metachronous cancer. Patients' characteristics, operative details, and endoscopical follow-up findings were retrieved. Multivariate survival analyses were used to identify patient categories at risk of metachronous colonic lesions.RESULTS: 128 patients presented a metachronous lesion: 118 adenomas and 10 adenocarcinomas. At multivariate analysis, active smoke (HR = 1.84, p = 0.03), neoadjuvant therapy (HR = 0.24, p = 0.01), and presence of synchronous polyps (HR = 1.55, p = 0.04) resulted independent predictors of metachronous adenoma after CRC removal while neoadjuvant therapy (HR = 0.25, p = 0.02), active smoke (HR = 1.54, p = 0.04), and presence of synchronous polyps (HR = 1.86, p = 0.02) resulted independent predictors of metachronous lesions after CRC removal.CONCLUSIONS: This study demonstrated a high rate of metachronous lesions in the early follow-up after curative CRC resection. The negative effects of synchronous polyps should be carefully evaluated when planning patients' follow-up.

AB - BACKGROUND: The principal aim of endoscopic follow-up programs after curative resection of colorectal cancer (CRC) is to improve survival and identify local recurrence and metachronous CRC. The aim of our study was to identify the possible predictors of metachronous colorectal lesions.METHODS: The records of 348 consecutive patients with CRC and who completed at least 1 year of endoscopic follow-up after surgery were analyzed. In this group, 336 patients underwent surgery for primitive CRC and 12 for metachronous cancer. Patients' characteristics, operative details, and endoscopical follow-up findings were retrieved. Multivariate survival analyses were used to identify patient categories at risk of metachronous colonic lesions.RESULTS: 128 patients presented a metachronous lesion: 118 adenomas and 10 adenocarcinomas. At multivariate analysis, active smoke (HR = 1.84, p = 0.03), neoadjuvant therapy (HR = 0.24, p = 0.01), and presence of synchronous polyps (HR = 1.55, p = 0.04) resulted independent predictors of metachronous adenoma after CRC removal while neoadjuvant therapy (HR = 0.25, p = 0.02), active smoke (HR = 1.54, p = 0.04), and presence of synchronous polyps (HR = 1.86, p = 0.02) resulted independent predictors of metachronous lesions after CRC removal.CONCLUSIONS: This study demonstrated a high rate of metachronous lesions in the early follow-up after curative CRC resection. The negative effects of synchronous polyps should be carefully evaluated when planning patients' follow-up.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Colectomy

KW - Colonoscopy

KW - Colorectal Neoplasms

KW - Databases, Factual

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Recurrence, Local

KW - Neoplasms, Multiple Primary

KW - Neoplasms, Second Primary

KW - Polyps

KW - Retrospective Studies

KW - Risk Assessment

KW - Survival Analysis

KW - Treatment Outcome

KW - Journal Article

KW - Multicenter Study

U2 - 10.1080/00015458.2016.1171075

DO - 10.1080/00015458.2016.1171075

M3 - Article

C2 - 27426670

VL - 116

SP - 225

EP - 230

JO - Acta Chirurgica Belgica

JF - Acta Chirurgica Belgica

SN - 0001-5458

IS - 4

ER -