Synchronous unicentric castleman disease and inflammatory hepatocellular adenoma: A case report

Claudio De Vito, G. Thomas Papathomas, Federica Pedica, Pauline Kane, Ali Amir, Nigel Heaton, Alberto Quaglia

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm ar-terialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalAnnals of Hepatology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Amyloidosis
  • Hepatocellular adenoma
  • Interleukin-6
  • Systemic symptoms
  • Unicentric plasma cell type castleman disease

ASJC Scopus subject areas

  • Hepatology

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