Abstract
In the perspective of clinical translation of stem cell research, the possibility to detect donor cells after transplantation and to track their fate is fundamental for a better understanding of their role in the regeneration of damaged tissues. In this article we summarize the results of ex-vivo and in-vivo X-ray computed microtomography experiments for 3D visualization of stem cells labeled with iron oxide nanoparticles and transplanted via intra-arterial infusion. We show that X-ray computed microtomography offers the possibility to detect with high definition and resolution human cells after transplantation, and opens new possibilities for experimental stem cell research.
| Original language | English |
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| Title of host publication | Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 |
| Pages | 81-84 |
| Number of pages | 4 |
| Volume | 3 |
| Publication status | Published - 2010 |
| Event | Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States Duration: Jun 21 2010 → Jun 24 2010 |
Other
| Other | Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 |
|---|---|
| Country | United States |
| City | Anaheim, CA |
| Period | 6/21/10 → 6/24/10 |
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Keywords
- Muscular dystrophy
- Nanoparticle labeling
- Stem cells
- X-ray computed microtomography
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
- Electrical and Electronic Engineering
Cite this
Fiori, F., Farini, A., Giuliani, A., Manescu, A., Villa, C., & Torrente, Y. (2010). Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue. In Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 (Vol. 3, pp. 81-84)