Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue

F. Fiori, A. Farini, A. Giuliani, A. Manescu, C. Villa, Y. Torrente

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the perspective of clinical translation of stem cell research, the possibility to detect donor cells after transplantation and to track their fate is fundamental for a better understanding of their role in the regeneration of damaged tissues. In this article we summarize the results of ex-vivo and in-vivo X-ray computed microtomography experiments for 3D visualization of stem cells labeled with iron oxide nanoparticles and transplanted via intra-arterial infusion. We show that X-ray computed microtomography offers the possibility to detect with high definition and resolution human cells after transplantation, and opens new possibilities for experimental stem cell research.

Original languageEnglish
Title of host publicationNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Pages81-84
Number of pages4
Volume3
Publication statusPublished - 2010
EventNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States
Duration: Jun 21 2010Jun 24 2010

Other

OtherNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
CountryUnited States
CityAnaheim, CA
Period6/21/106/24/10

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Keywords

  • Muscular dystrophy
  • Nanoparticle labeling
  • Stem cells
  • X-ray computed microtomography

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Fiori, F., Farini, A., Giuliani, A., Manescu, A., Villa, C., & Torrente, Y. (2010). Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue. In Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 (Vol. 3, pp. 81-84)