Syncope and Epilepsy coexist in 'possible' and 'drug-resistant' epilepsy (Overlap between Epilepsy and Syncope Study - OESYS)

Andrea Ungar, Alice Ceccofiglio, Francesca Pescini, Chiara Mussi, Gianni Tava, Martina Rafanelli, Assunta Langellotto, Niccolò Marchionni, J. Gert van Dijk, Gianlugi Galizia, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Differential diagnosis between syncope and epilepsy in patients with transient loss of consciousness of uncertain etiology is still unclear. Thus, the aim of the present work is to evaluate the prevalence of syncope in patients with "possible" or "drug-resistant" epilepsy.

METHODS: The Overlap between Epilepsy and SYncope Study (OESYS) is a multicenter prospective observational study designed to estimate the prevalence of syncope in patients followed in Epilepsy Centers for "possible" or "drug-resistant" epilepsy and assessed according the European Society of Cardiology (ESC) guidelines of syncope diagnosis.

RESULTS: One hundred seven patients were evaluated; 63 (58.9%) had possible and 44 (41.1%) drug-resistant epilepsy. A final diagnosis of isolated syncope was in 45 patients (42.1%), all with possible epilepsy (45/63, 71.4%). Isolated epilepsy was found in 21 patients (19.6%) and it was more frequent in the drug-resistant than in the possible epilepsy group (34.1% vs. 9.5%, p = 0.002). More importantly, syncope and epilepsy coexisted in 37.4% of all patients but the coexistence was more frequent among patients with drug-resistant than possible epilepsy (65.9% vs. 17.5%, p < 0.001).

CONCLUSIONS: Isolated syncope was diagnosed in ≈ 70% of patients with possible epilepsy. Syncope and epilepsy coexisted in ≈ 20% of patients with possible and in ≈ 60% of patients with drug-resistant epilepsy. These findings highlight the need of ESC guidelines of syncope approach in patients with possible and drug-resistant epilepsy.

Original languageEnglish
Pages (from-to)45
JournalBMC Neurology
Volume17
Issue number1
DOIs
Publication statusPublished - Feb 28 2017

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Syncope
Epilepsy
Drug Resistant Epilepsy
Guidelines
Unconsciousness
Cardiology
Observational Studies
Differential Diagnosis
Prospective Studies

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Diagnosis, Differential
  • Epilepsy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Syncope
  • Young Adult
  • Journal Article
  • Multicenter Study
  • Observational Study

Cite this

Syncope and Epilepsy coexist in 'possible' and 'drug-resistant' epilepsy (Overlap between Epilepsy and Syncope Study - OESYS). / Ungar, Andrea; Ceccofiglio, Alice; Pescini, Francesca; Mussi, Chiara; Tava, Gianni; Rafanelli, Martina; Langellotto, Assunta; Marchionni, Niccolò; van Dijk, J. Gert; Galizia, Gianlugi; Bonaduce, Domenico; Abete, Pasquale.

In: BMC Neurology, Vol. 17, No. 1, 28.02.2017, p. 45.

Research output: Contribution to journalArticle

Ungar, A, Ceccofiglio, A, Pescini, F, Mussi, C, Tava, G, Rafanelli, M, Langellotto, A, Marchionni, N, van Dijk, JG, Galizia, G, Bonaduce, D & Abete, P 2017, 'Syncope and Epilepsy coexist in 'possible' and 'drug-resistant' epilepsy (Overlap between Epilepsy and Syncope Study - OESYS)', BMC Neurology, vol. 17, no. 1, pp. 45. https://doi.org/10.1186/s12883-017-0822-5
Ungar, Andrea ; Ceccofiglio, Alice ; Pescini, Francesca ; Mussi, Chiara ; Tava, Gianni ; Rafanelli, Martina ; Langellotto, Assunta ; Marchionni, Niccolò ; van Dijk, J. Gert ; Galizia, Gianlugi ; Bonaduce, Domenico ; Abete, Pasquale. / Syncope and Epilepsy coexist in 'possible' and 'drug-resistant' epilepsy (Overlap between Epilepsy and Syncope Study - OESYS). In: BMC Neurology. 2017 ; Vol. 17, No. 1. pp. 45.
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T1 - Syncope and Epilepsy coexist in 'possible' and 'drug-resistant' epilepsy (Overlap between Epilepsy and Syncope Study - OESYS)

AU - Ungar, Andrea

AU - Ceccofiglio, Alice

AU - Pescini, Francesca

AU - Mussi, Chiara

AU - Tava, Gianni

AU - Rafanelli, Martina

AU - Langellotto, Assunta

AU - Marchionni, Niccolò

AU - van Dijk, J. Gert

AU - Galizia, Gianlugi

AU - Bonaduce, Domenico

AU - Abete, Pasquale

PY - 2017/2/28

Y1 - 2017/2/28

N2 - BACKGROUND: Differential diagnosis between syncope and epilepsy in patients with transient loss of consciousness of uncertain etiology is still unclear. Thus, the aim of the present work is to evaluate the prevalence of syncope in patients with "possible" or "drug-resistant" epilepsy.METHODS: The Overlap between Epilepsy and SYncope Study (OESYS) is a multicenter prospective observational study designed to estimate the prevalence of syncope in patients followed in Epilepsy Centers for "possible" or "drug-resistant" epilepsy and assessed according the European Society of Cardiology (ESC) guidelines of syncope diagnosis.RESULTS: One hundred seven patients were evaluated; 63 (58.9%) had possible and 44 (41.1%) drug-resistant epilepsy. A final diagnosis of isolated syncope was in 45 patients (42.1%), all with possible epilepsy (45/63, 71.4%). Isolated epilepsy was found in 21 patients (19.6%) and it was more frequent in the drug-resistant than in the possible epilepsy group (34.1% vs. 9.5%, p = 0.002). More importantly, syncope and epilepsy coexisted in 37.4% of all patients but the coexistence was more frequent among patients with drug-resistant than possible epilepsy (65.9% vs. 17.5%, p < 0.001).CONCLUSIONS: Isolated syncope was diagnosed in ≈ 70% of patients with possible epilepsy. Syncope and epilepsy coexisted in ≈ 20% of patients with possible and in ≈ 60% of patients with drug-resistant epilepsy. These findings highlight the need of ESC guidelines of syncope approach in patients with possible and drug-resistant epilepsy.

AB - BACKGROUND: Differential diagnosis between syncope and epilepsy in patients with transient loss of consciousness of uncertain etiology is still unclear. Thus, the aim of the present work is to evaluate the prevalence of syncope in patients with "possible" or "drug-resistant" epilepsy.METHODS: The Overlap between Epilepsy and SYncope Study (OESYS) is a multicenter prospective observational study designed to estimate the prevalence of syncope in patients followed in Epilepsy Centers for "possible" or "drug-resistant" epilepsy and assessed according the European Society of Cardiology (ESC) guidelines of syncope diagnosis.RESULTS: One hundred seven patients were evaluated; 63 (58.9%) had possible and 44 (41.1%) drug-resistant epilepsy. A final diagnosis of isolated syncope was in 45 patients (42.1%), all with possible epilepsy (45/63, 71.4%). Isolated epilepsy was found in 21 patients (19.6%) and it was more frequent in the drug-resistant than in the possible epilepsy group (34.1% vs. 9.5%, p = 0.002). More importantly, syncope and epilepsy coexisted in 37.4% of all patients but the coexistence was more frequent among patients with drug-resistant than possible epilepsy (65.9% vs. 17.5%, p < 0.001).CONCLUSIONS: Isolated syncope was diagnosed in ≈ 70% of patients with possible epilepsy. Syncope and epilepsy coexisted in ≈ 20% of patients with possible and in ≈ 60% of patients with drug-resistant epilepsy. These findings highlight the need of ESC guidelines of syncope approach in patients with possible and drug-resistant epilepsy.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Diagnosis, Differential

KW - Epilepsy

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Syncope

KW - Young Adult

KW - Journal Article

KW - Multicenter Study

KW - Observational Study

U2 - 10.1186/s12883-017-0822-5

DO - 10.1186/s12883-017-0822-5

M3 - Article

C2 - 28241809

VL - 17

SP - 45

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

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ER -