Synergic effect of fludrocortisone and disopyramide in an elderly patient with orthostatic syncope

Assunta Langellotto, Gianluigi Galizia, Gianluca Testa, Andrea Ungar, Franco Rengo, Pasquale Abete

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Orthostatic hypotension (OH) is a debilitating condition very common in the elderly that may leads to syncope. There is no single drug able to limit the fall in blood pressure in patients affected by OH when standing. In addition, the presence of hyperkinetic arrhythmias may worsen the fall in orthostatic blood pressure especially in elderly patients affected by OH. Unfortunately most of antiarrhythmic therapies lead to a decrease in blood pressure contrasting the effect of OH treatment. By contrast, disopyramide seems to have an anticholinergic effect that could play an important role in limiting the fall in blood pressure in participants with hyperkinetic arrhythmias and OH. We report a case of successful combination therapy of fludrocortisone, disopyramide and nonpharmacologic treatment in an elderly participant affected by neurogenic orthostatic OH and hyperkinetic arrhythmias with a poor quality of life and frequent syncope episodes.

Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalInternational Journal of Gerontology
Volume7
Issue number2
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Fludrocortisone
Disopyramide
Orthostatic Hypotension
Syncope
Blood Pressure
Cardiac Arrhythmias
Cholinergic Antagonists
Therapeutics
Quality of Life
Pharmaceutical Preparations

Keywords

  • elderly
  • orthostatic hypotension
  • syncope

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Synergic effect of fludrocortisone and disopyramide in an elderly patient with orthostatic syncope. / Langellotto, Assunta; Galizia, Gianluigi; Testa, Gianluca; Ungar, Andrea; Rengo, Franco; Abete, Pasquale.

In: International Journal of Gerontology, Vol. 7, No. 2, 06.2013, p. 124-126.

Research output: Contribution to journalArticle

Langellotto, Assunta ; Galizia, Gianluigi ; Testa, Gianluca ; Ungar, Andrea ; Rengo, Franco ; Abete, Pasquale. / Synergic effect of fludrocortisone and disopyramide in an elderly patient with orthostatic syncope. In: International Journal of Gerontology. 2013 ; Vol. 7, No. 2. pp. 124-126.
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