Synergic effect of fludrocortisone and disopyramide in an elderly patient with orthostatic syncope

Assunta Langellotto, Gianluigi Galizia, Gianluca Testa, Andrea Ungar, Franco Rengo, Pasquale Abete

Research output: Contribution to journalArticlepeer-review


Orthostatic hypotension (OH) is a debilitating condition very common in the elderly that may leads to syncope. There is no single drug able to limit the fall in blood pressure in patients affected by OH when standing. In addition, the presence of hyperkinetic arrhythmias may worsen the fall in orthostatic blood pressure especially in elderly patients affected by OH. Unfortunately most of antiarrhythmic therapies lead to a decrease in blood pressure contrasting the effect of OH treatment. By contrast, disopyramide seems to have an anticholinergic effect that could play an important role in limiting the fall in blood pressure in participants with hyperkinetic arrhythmias and OH. We report a case of successful combination therapy of fludrocortisone, disopyramide and nonpharmacologic treatment in an elderly participant affected by neurogenic orthostatic OH and hyperkinetic arrhythmias with a poor quality of life and frequent syncope episodes.

Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalInternational Journal of Gerontology
Issue number2
Publication statusPublished - Jun 2013


  • elderly
  • orthostatic hypotension
  • syncope

ASJC Scopus subject areas

  • Geriatrics and Gerontology


Dive into the research topics of 'Synergic effect of fludrocortisone and disopyramide in an elderly patient with orthostatic syncope'. Together they form a unique fingerprint.

Cite this